Coexpression cluster:C2039

Full id: C2039_signet_corpus_optic_spinal_globus_thalamus_medulla

Phase1 CAGE Peaks

Hg19::chr10:123357854..123357865,-	p6@FGFR2
Hg19::chr9:130713012..130713034,-	p5@FAM102A
Hg19::chrX:70443019..70443030,+	p6@GJB1
Hg19::chrX:70443050..70443061,+	p5@GJB1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0005007	fibroblast growth factor receptor activity	0.0261372497981506
GO:0005922	connexon complex	0.0493500129061144
GO:0005921	gap junction	0.0493500129061144

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

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Uber Anatomy

Ontology term	p-value	n
neural tube	2.69e-73	56
neural rod	2.69e-73	56
future spinal cord	2.69e-73	56
neural keel	2.69e-73	56
regional part of nervous system	1.44e-66	53
regional part of brain	1.44e-66	53
adult organism	1.52e-66	114
central nervous system	9.25e-59	81
neural plate	3.96e-56	82
presumptive neural plate	3.96e-56	82
regional part of forebrain	3.83e-55	41
forebrain	3.83e-55	41
anterior neural tube	3.83e-55	41
future forebrain	3.83e-55	41
nervous system	2.85e-54	89
brain	4.36e-54	68
future brain	4.36e-54	68
neurectoderm	6.75e-53	86
brain grey matter	1.35e-51	34
gray matter	1.35e-51	34
telencephalon	1.52e-51	34
regional part of telencephalon	5.61e-47	32
cerebral hemisphere	8.37e-47	32
ecto-epithelium	1.69e-43	104
pre-chordal neural plate	1.65e-41	61
structure with developmental contribution from neural crest	1.55e-34	132
regional part of cerebral cortex	1.02e-33	22
cerebral cortex	3.19e-32	25
pallium	3.19e-32	25
ectoderm-derived structure	3.33e-32	171
ectoderm	3.33e-32	171
presumptive ectoderm	3.33e-32	171
organ system subdivision	7.21e-30	223
neocortex	9.49e-30	20
neural nucleus	1.33e-21	9
nucleus of brain	1.33e-21	9
tube	4.87e-19	192
posterior neural tube	2.03e-18	15
chordal neural plate	2.03e-18	15
telencephalic nucleus	6.73e-17	7
anatomical conduit	1.27e-16	240
basal ganglion	1.52e-16	9
nuclear complex of neuraxis	1.52e-16	9
aggregate regional part of brain	1.52e-16	9
collection of basal ganglia	1.52e-16	9
cerebral subcortex	1.52e-16	9
brainstem	1.49e-15	6
anatomical cluster	1.91e-15	373
segmental subdivision of nervous system	1.84e-14	13
parietal lobe	2.01e-12	5
occipital lobe	2.11e-12	5
segmental subdivision of hindbrain	2.32e-12	12
hindbrain	2.32e-12	12
presumptive hindbrain	2.32e-12	12
multi-tissue structure	3.18e-12	342
organ part	1.39e-11	218
organ	2.44e-10	503
gyrus	3.06e-10	6
epithelium	3.89e-10	306
cell layer	6.60e-10	309
corpus striatum	1.00e-09	4
striatum	1.00e-09	4
ventral part of telencephalon	1.00e-09	4
future corpus striatum	1.00e-09	4
pons	1.09e-08	3
medulla oblongata	1.50e-08	3
myelencephalon	1.50e-08	3
future myelencephalon	1.50e-08	3
spinal cord	1.83e-08	3
dorsal region element	1.83e-08	3
dorsum	1.83e-08	3
limbic system	8.73e-08	5
caudate-putamen	1.29e-07	3
dorsal striatum	1.29e-07	3
embryo	5.26e-07	592
regional part of metencephalon	9.63e-07	9
metencephalon	9.63e-07	9
future metencephalon	9.63e-07	9

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.