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Coexpression cluster:C1745

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Full id: C1745_cerebellum_small_optic_hippocampus_occipital_Neural_spinal



Phase1 CAGE Peaks

  Short description
Hg19::chr15:66375007..66375011,- p@chr15:66375007..66375011
-
Hg19::chr15:66546082..66546094,- p1@MEGF11
Hg19::chr15:66546108..66546115,- p3@MEGF11
Hg19::chr15:66546121..66546132,- p2@MEGF11
Hg19::chr7:75902381..75902400,+ p4@SRRM3


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0016323basolateral plasma membrane0.0200164841634287



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
neural cell1.24e-0725
Uber Anatomy
Ontology termp-valuen
neural tube1.22e-7256
neural rod1.22e-7256
future spinal cord1.22e-7256
neural keel1.22e-7256
central nervous system8.69e-6981
nervous system1.98e-6789
regional part of nervous system2.81e-6753
regional part of brain2.81e-6753
brain7.85e-5668
future brain7.85e-5668
neurectoderm1.52e-5286
regional part of forebrain9.38e-5241
forebrain9.38e-5241
anterior neural tube9.38e-5241
future forebrain9.38e-5241
neural plate2.05e-5182
presumptive neural plate2.05e-5182
brain grey matter1.04e-4634
gray matter1.04e-4634
telencephalon2.71e-4634
regional part of telencephalon7.02e-4332
cerebral hemisphere7.51e-4332
ecto-epithelium4.79e-41104
pre-chordal neural plate1.78e-3761
ectoderm-derived structure4.59e-36171
ectoderm4.59e-36171
presumptive ectoderm4.59e-36171
structure with developmental contribution from neural crest1.61e-31132
cerebral cortex2.22e-3025
pallium2.22e-3025
organ system subdivision1.69e-27223
regional part of cerebral cortex6.35e-2622
adult organism2.11e-25114
neocortex2.41e-2220
posterior neural tube4.29e-2115
chordal neural plate4.29e-2115
neural nucleus3.78e-189
nucleus of brain3.78e-189
segmental subdivision of hindbrain4.39e-1612
hindbrain4.39e-1612
presumptive hindbrain4.39e-1612
tube2.96e-15192
segmental subdivision of nervous system1.19e-1413
telencephalic nucleus2.54e-147
basal ganglion2.79e-149
nuclear complex of neuraxis2.79e-149
aggregate regional part of brain2.79e-149
collection of basal ganglia2.79e-149
cerebral subcortex2.79e-149
anatomical cluster7.75e-14373
gyrus9.30e-136
brainstem2.30e-126
regional part of metencephalon5.11e-119
metencephalon5.11e-119
future metencephalon5.11e-119
organ part3.54e-10218
anatomical conduit5.03e-10240
epithelium2.30e-09306
cell layer3.97e-09309
corpus striatum4.60e-094
striatum4.60e-094
ventral part of telencephalon4.60e-094
future corpus striatum4.60e-094
caudate-putamen2.24e-073
dorsal striatum2.24e-073
multi-tissue structure2.54e-07342
limbic system2.86e-075
occipital lobe3.41e-075
parietal lobe3.99e-075
pons4.33e-073
diencephalon4.88e-077
future diencephalon4.88e-077
medulla oblongata6.35e-073
myelencephalon6.35e-073
future myelencephalon6.35e-073
frontal cortex7.16e-073
spinal cord9.46e-073
dorsal region element9.46e-073
dorsum9.46e-073


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.24383
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.369468
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.14.0988
MA0056.10
MA0057.10.554727
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.0469445
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.818263
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.442008
MA0146.10.143081
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.527987
MA0138.20.837782
MA0002.20.83106
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.136971
MA0065.20.449243
MA0150.10.550239
MA0151.10
MA0152.11.66846
MA0153.11.21379
MA0154.10.172764
MA0155.11.91168
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.168633
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.636989
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488337.63020020359693.95343056005017e-050.000737571158022651
SUZ12#23512330.06946854663777.70283100694034e-050.00118829537301897



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.