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Coexpression cluster:C2231

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Full id: C2231_extraskeletal_eye_lung_retina_brain_nucleus_pituitary



Phase1 CAGE Peaks

  Short description
Hg19::chr12:65514991..65515002,- p9@WIF1
Hg19::chr12:65515010..65515019,- p11@WIF1
Hg19::chr12:65515035..65515066,- p2@WIF1
Hg19::chr12:65515072..65515111,- p1@WIF1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
adult organism5.75e-61114
neural tube1.17e-4856
neural rod1.17e-4856
future spinal cord1.17e-4856
neural keel1.17e-4856
regional part of nervous system2.18e-4753
regional part of brain2.18e-4753
regional part of forebrain4.27e-4341
forebrain4.27e-4341
anterior neural tube4.27e-4341
future forebrain4.27e-4341
central nervous system1.57e-3781
brain1.83e-3768
future brain1.83e-3768
telencephalon1.35e-3534
brain grey matter7.84e-3534
gray matter7.84e-3534
neural plate7.45e-3482
presumptive neural plate7.45e-3482
cerebral hemisphere2.82e-3332
regional part of telencephalon9.69e-3332
nervous system2.67e-3289
neurectoderm1.35e-3186
pre-chordal neural plate2.45e-2761
regional part of cerebral cortex1.37e-2622
structure with developmental contribution from neural crest6.83e-26132
ecto-epithelium5.96e-25104
neocortex9.86e-2420
cerebral cortex9.16e-2325
pallium9.16e-2325
organ system subdivision1.11e-22223
ectoderm-derived structure4.69e-20171
ectoderm4.69e-20171
presumptive ectoderm4.69e-20171
basal ganglion6.31e-159
nuclear complex of neuraxis6.31e-159
aggregate regional part of brain6.31e-159
collection of basal ganglia6.31e-159
cerebral subcortex6.31e-159
neural nucleus7.04e-149
nucleus of brain7.04e-149
multi-tissue structure8.54e-13342
telencephalic nucleus6.17e-127
anatomical conduit6.71e-12240
anatomical cluster9.66e-12373
tube2.58e-11192
gyrus6.41e-116
embryo2.23e-09592
organ part2.39e-09218
limbic system2.99e-095
diencephalon8.69e-097
future diencephalon8.69e-097
temporal lobe1.06e-086
organ1.15e-08503
corpus striatum2.78e-084
striatum2.78e-084
ventral part of telencephalon2.78e-084
future corpus striatum2.78e-084
multi-cellular organism8.10e-08656
posterior neural tube9.79e-0815
chordal neural plate9.79e-0815
embryonic structure2.36e-07564
developing anatomical structure3.09e-07581
epithelium3.67e-07306
germ layer4.03e-07560
germ layer / neural crest4.03e-07560
embryonic tissue4.03e-07560
presumptive structure4.03e-07560
germ layer / neural crest derived structure4.03e-07560
epiblast (generic)4.03e-07560
cell layer6.02e-07309


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.443649
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.524262
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.709734
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.12.526
MA0056.10
MA0057.11.98521
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.100363
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.11.57689
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.12.87436
MA0145.10.195821
MA0146.11.75643
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.23.4512
MA0104.20.392359
MA0047.20.856092
MA0112.21.05083
MA0065.21.09513
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.12.80246
MA0163.10.253219
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.24.91669
MA0102.21.75932
MA0258.11.07498
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTCF#1066445.360256373075030.001211145381643620.00816175071063868
MYC#460945.22228187160940.001344309395272740.00886297133595665
SUZ12#23512450.11578091106291.5827390373096e-078.78786189886113e-06
TBP#690843.706770687096390.005296377814784350.0243666976167685
ZNF263#1012748.221841637010680.0002187871180958320.0024815277831028



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.