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Coexpression cluster:C2431

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Full id: C2431_heart_thalamus_substantia_spinal_corpus_globus_ovary



Phase1 CAGE Peaks

  Short description
Hg19::chr17:66951400..66951411,- p4@ABCA8
Hg19::chr17:66951415..66951429,- p2@ABCA8
Hg19::chr17:66951430..66951441,- p3@ABCA8
Hg19::chr17:66951474..66951550,- p1@ABCA8


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
adult organism5.55e-80114
neural tube2.95e-4156
neural rod2.95e-4156
future spinal cord2.95e-4156
neural keel2.95e-4156
regional part of nervous system5.34e-3853
regional part of brain5.34e-3853
regional part of forebrain1.91e-3241
forebrain1.91e-3241
anterior neural tube1.91e-3241
future forebrain1.91e-3241
brain4.08e-3268
future brain4.08e-3268
central nervous system2.62e-3181
neural plate7.15e-3182
presumptive neural plate7.15e-3182
neurectoderm1.61e-2986
nervous system1.35e-2789
structure with developmental contribution from neural crest1.79e-26132
brain grey matter2.23e-2534
gray matter2.23e-2534
telencephalon2.71e-2534
regional part of telencephalon3.29e-2332
cerebral hemisphere5.58e-2332
ecto-epithelium3.63e-22104
pre-chordal neural plate3.50e-2061
regional part of cerebral cortex1.63e-1922
anatomical conduit6.17e-19240
organ system subdivision1.51e-18223
tube1.58e-18192
neocortex7.35e-1820
multi-tissue structure4.03e-17342
cerebral cortex2.40e-1625
pallium2.40e-1625
anatomical cluster4.32e-16373
ectoderm-derived structure5.35e-15171
ectoderm5.35e-15171
presumptive ectoderm5.35e-15171
epithelium8.70e-13306
cell layer2.21e-12309
organ1.23e-11503
neural nucleus6.26e-119
nucleus of brain6.26e-119
multi-cellular organism1.22e-10656
basal ganglion2.94e-109
nuclear complex of neuraxis2.94e-109
aggregate regional part of brain2.94e-109
collection of basal ganglia2.94e-109
cerebral subcortex2.94e-109
posterior neural tube7.32e-1015
chordal neural plate7.32e-1015
embryonic structure9.48e-10564
germ layer1.14e-09560
germ layer / neural crest1.14e-09560
embryonic tissue1.14e-09560
presumptive structure1.14e-09560
germ layer / neural crest derived structure1.14e-09560
epiblast (generic)1.14e-09560
embryo5.36e-09592
developing anatomical structure5.46e-09581
diencephalon1.01e-087
future diencephalon1.01e-087
telencephalic nucleus1.05e-087
tissue1.77e-08773
organ part2.38e-08218
brainstem2.57e-086
primary circulatory organ2.83e-0827
segmental subdivision of nervous system6.15e-0813
anatomical system8.50e-08624
anatomical group1.02e-07625
temporal lobe1.71e-076
blood vessel layer2.34e-077
gyrus3.69e-076
segmental subdivision of hindbrain5.73e-0712
hindbrain5.73e-0712
presumptive hindbrain5.73e-0712


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.11.91805
MA0052.11.12718
MA0055.10.125954
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.00636811
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.23.84935
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.11.09982
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.12.93423
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.22.35208
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.22.02192
MA0099.20.7872
MA0079.20.000248021
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
HEY1#2346244.040111043105710.00375304636917980.0185976660538418
SRF#6722413.79717826216782.75840773062708e-050.000584114649186863
TAF1#687243.343046285745290.008005664898701650.0322086226879118
TBP#690843.706770687096390.005296377814784350.0244107856398174



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.