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{{Coexpression_clusters
{{Coexpression_clusters|coexpression_dpi_cluster_scores_median=0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0534545700183436,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0672629396841865,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.600149562354411,0.472664584088588,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.441317043034033,0,0,0,0,0,0,0,0,0,0,0,0.448543479856398,0,0.0867720438244607,0.112453380477913,0.219625436886832,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.103668463987428,0,0.0914082188667263,0,0,0,0,0,0.115967372264001,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0884836478019413,0,0,0.532220447716328,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.105104912336182,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.254120022070344,0.463422275990261,0,0,0,0,0,0.368563972430626,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0998759650431728,0.145102450696258,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.487766940539148,0.419539765898424,0,0.124760798356953,0.137537165784479,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.401545763473513,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.32054026111017,0,0.254830577579197,0.348440814002821,0,0.210162025788965,0.257049046425766,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.289037080308482,0.250682963288844,0.456393542916647,0.261121380571535,0,0,0,0,0,0,0,0.206006581150341,0.687551901788655,0,0,0,0.0285589446518912,0.339234721825982,0,0,0,0.564780247219722,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.0778431765528363,0.112955512742184,0.15309981666883,0,0,0,0,0,0,0,0,0,0,0,0.259091422156153,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0.150367083334639,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0|full_id=C4395_putamen_pituitary_frontal_caudate_amygdala_nucleus_cerebral|gostat_on_coexpression_clusters=GO:0016934!extracellular-glycine-gated chloride channel activity!0.00824159647213382!8001$GO:0016933!extracellular-glycine-gated ion channel activity!0.00824159647213382!8001$GO:0004890!GABA-A receptor activity!0.0283886005769037!8001$GO:0016917!GABA receptor activity!0.0283886005769037!8001$GO:0043168!anion binding!0.0283886005769037!8001$GO:0031404!chloride ion binding!0.0283886005769037!8001$GO:0005231!excitatory extracellular ligand-gated ion channel activity!0.0283886005769037!8001$GO:0044459!plasma membrane part!0.0283886005769037!8001;2823$GO:0005254!chloride channel activity!0.0283886005769037!8001$GO:0006821!chloride transport!0.0283886005769037!8001$GO:0005253!anion channel activity!0.0283886005769037!8001$GO:0005230!extracellular ligand-gated ion channel activity!0.0283886005769037!8001$GO:0030594!neurotransmitter receptor activity!0.0283886005769037!8001$GO:0042165!neurotransmitter binding!0.0283886005769037!8001$GO:0009986!cell surface!0.0283886005769037!2823$GO:0045211!postsynaptic 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|full_id=C4395_putamen_pituitary_frontal_caudate_amygdala_nucleus_cerebral
|gostat_on_coexpression_clusters=GO:0016934!extracellular-glycine-gated chloride channel activity!0.00824159647213382!8001$GO:0016933!extracellular-glycine-gated ion channel activity!0.00824159647213382!8001$GO:0004890!GABA-A receptor activity!0.0283886005769037!8001$GO:0016917!GABA receptor activity!0.0283886005769037!8001$GO:0043168!anion binding!0.0283886005769037!8001$GO:0031404!chloride ion binding!0.0283886005769037!8001$GO:0005231!excitatory extracellular ligand-gated ion channel activity!0.0283886005769037!8001$GO:0044459!plasma membrane part!0.0283886005769037!8001;2823$GO:0005254!chloride channel activity!0.0283886005769037!8001$GO:0006821!chloride transport!0.0283886005769037!8001$GO:0005253!anion channel activity!0.0283886005769037!8001$GO:0005230!extracellular ligand-gated ion channel activity!0.0283886005769037!8001$GO:0030594!neurotransmitter receptor activity!0.0283886005769037!8001$GO:0042165!neurotransmitter binding!0.0283886005769037!8001$GO:0009986!cell surface!0.0283886005769037!2823$GO:0045211!postsynaptic membrane!0.0283886005769037!8001$GO:0044456!synapse part!0.0283886005769037!8001$GO:0015276!ligand-gated ion channel activity!0.0283886005769037!8001$GO:0022834!ligand-gated channel activity!0.0283886005769037!8001$GO:0008509!anion transmembrane transporter activity!0.0336389316043571!8001$GO:0005886!plasma membrane!0.0336389316043571!8001;2823$GO:0015698!inorganic anion transport!0.0388140398722077!8001$GO:0007268!synaptic transmission!0.0413919419054682!8001$GO:0006820!anion transport!0.0433074604608263!8001$GO:0019226!transmission of nerve impulse!0.0433074604608263!8001
|id=C4395
}}

Latest revision as of 12:45, 17 September 2013


Full id: C4395_putamen_pituitary_frontal_caudate_amygdala_nucleus_cerebral



Phase1 CAGE Peaks

Hg19::chr4:175750301..175750313,-p2@GLRA3
Hg19::chr4:176828294..176828305,-p31@GPM6A
Hg19::chr5:156772645..156772690,-p1@FNDC9


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

GO IDGO nameFDR corrected p-value
GO:0016934extracellular-glycine-gated chloride channel activity0.00824159647213382
GO:0016933extracellular-glycine-gated ion channel activity0.00824159647213382
GO:0004890GABA-A receptor activity0.0283886005769037
GO:0016917GABA receptor activity0.0283886005769037
GO:0043168anion binding0.0283886005769037
GO:0031404chloride ion binding0.0283886005769037
GO:0005231excitatory extracellular ligand-gated ion channel activity0.0283886005769037
GO:0044459plasma membrane part0.0283886005769037
GO:0005254chloride channel activity0.0283886005769037
GO:0006821chloride transport0.0283886005769037
GO:0005253anion channel activity0.0283886005769037
GO:0005230extracellular ligand-gated ion channel activity0.0283886005769037
GO:0030594neurotransmitter receptor activity0.0283886005769037
GO:0042165neurotransmitter binding0.0283886005769037
GO:0009986cell surface0.0283886005769037
GO:0045211postsynaptic membrane0.0283886005769037
GO:0044456synapse part0.0283886005769037
GO:0015276ligand-gated ion channel activity0.0283886005769037
GO:0022834ligand-gated channel activity0.0283886005769037
GO:0008509anion transmembrane transporter activity0.0336389316043571
GO:0005886plasma membrane0.0336389316043571
GO:0015698inorganic anion transport0.0388140398722077
GO:0007268synaptic transmission0.0413919419054682
GO:0006820anion transport0.0433074604608263
GO:0019226transmission of nerve impulse0.0433074604608263



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>

Uber Anatomy
Ontology termp-valuen
neural tube6.33e-11056
neural rod6.33e-11056
future spinal cord6.33e-11056
neural keel6.33e-11056
regional part of nervous system2.25e-9853
regional part of brain2.25e-9853
central nervous system4.39e-8681
regional part of forebrain5.70e-8241
forebrain5.70e-8241
anterior neural tube5.70e-8241
future forebrain5.70e-8241
brain6.04e-7968
future brain6.04e-7968
nervous system6.74e-7789
neural plate4.24e-7382
presumptive neural plate4.24e-7382
telencephalon1.26e-7234
brain grey matter1.92e-7234
gray matter1.92e-7234
cerebral hemisphere4.26e-7132
neurectoderm2.19e-6986
regional part of telencephalon7.80e-6532
regional part of cerebral cortex3.93e-6322
ecto-epithelium3.61e-56104
cerebral cortex2.39e-5525
pallium2.39e-5525
neocortex1.30e-5420
pre-chordal neural plate1.96e-5361
adult organism3.12e-51114
structure with developmental contribution from neural crest2.40e-45132
ectoderm-derived structure6.35e-37171
ectoderm6.35e-37171
presumptive ectoderm6.35e-37171
organ system subdivision4.24e-28223
posterior neural tube2.24e-2715
chordal neural plate2.24e-2715
tube5.36e-27192
temporal lobe2.47e-246
limbic system3.02e-245
gyrus4.77e-206
anatomical conduit4.79e-20240
basal ganglion7.35e-199
nuclear complex of neuraxis7.35e-199
aggregate regional part of brain7.35e-199
collection of basal ganglia7.35e-199
cerebral subcortex7.35e-199
brainstem3.26e-186
neural nucleus4.33e-189
nucleus of brain4.33e-189
segmental subdivision of hindbrain4.76e-1712
hindbrain4.76e-1712
presumptive hindbrain4.76e-1712
segmental subdivision of nervous system1.14e-1513
parietal lobe1.77e-155
epithelium5.02e-14306
spinal cord7.24e-143
dorsal region element7.24e-143
dorsum7.24e-143
cell layer8.20e-14309
pons1.08e-133
anatomical cluster1.23e-13373
organ part1.90e-12218
regional part of metencephalon6.08e-129
metencephalon6.08e-129
future metencephalon6.08e-129
corpus striatum1.28e-114
striatum1.28e-114
ventral part of telencephalon1.28e-114
future corpus striatum1.28e-114
telencephalic nucleus4.30e-117
amygdala5.03e-112
middle temporal gyrus7.77e-112
diencephalon9.34e-117
future diencephalon9.34e-117
pituitary gland1.25e-102
Ammon's horn1.38e-102
lobe parts of cerebral cortex1.38e-102
hippocampal formation1.38e-102
limbic lobe1.38e-102
multi-tissue structure6.24e-10342
locus ceruleus7.68e-102
brainstem nucleus7.68e-102
hindbrain nucleus7.68e-102
occipital lobe5.38e-095
caudate-putamen1.47e-073
dorsal striatum1.47e-073
frontal cortex1.62e-073
organ3.02e-07503
medulla oblongata6.72e-073
myelencephalon6.72e-073
future myelencephalon6.72e-073


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0471418
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.11.58389
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.11.06172
MA0056.10
MA0057.10.333427
MA0058.10.716037
MA0059.10.714521
MA0060.11.23283
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0834661
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.107247
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.0373086
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

This analysis result is provided for C0 - C305 clusters.

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