Coexpression cluster:C3694

Full id: C3694_Cardiac_Smooth_Mesenchymal_mesenchymal_Hair_heart_Fibroblast

Phase1 CAGE Peaks

Hg19::chr17:77020146..77020158,+	p7@C1QTNF1
Hg19::chr17:77020171..77020195,+	p3@C1QTNF1
Hg19::chr17:77020477..77020492,+	p6@C1QTNF1

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

---

No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

---

No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>

---

Cell Type

Ontology term	p-value	n
muscle precursor cell	2.95e-23	58
myoblast	2.95e-23	58
multi-potent skeletal muscle stem cell	2.95e-23	58
contractile cell	5.51e-23	59
muscle cell	2.22e-22	55
smooth muscle cell	1.37e-20	43
smooth muscle myoblast	1.37e-20	43
electrically responsive cell	8.96e-18	61
electrically active cell	8.96e-18	61
vascular associated smooth muscle cell	4.16e-17	32
non-terminally differentiated cell	3.86e-13	106
cardiocyte	1.88e-12	16
mesodermal cell	5.23e-12	121
fibroblast	1.07e-08	76
embryonic cell	8.25e-08	250
aortic smooth muscle cell	1.02e-07	10

Uber Anatomy

Ontology term	p-value	n
multilaminar epithelium	3.64e-26	83
somite	1.68e-24	71
presomitic mesoderm	1.68e-24	71
presumptive segmental plate	1.68e-24	71
dermomyotome	1.68e-24	71
trunk paraxial mesoderm	1.68e-24	71
paraxial mesoderm	2.24e-24	72
presumptive paraxial mesoderm	2.24e-24	72
dense mesenchyme tissue	1.26e-23	73
skeletal muscle tissue	3.59e-22	62
striated muscle tissue	3.59e-22	62
myotome	3.59e-22	62
muscle tissue	2.27e-21	64
musculature	2.27e-21	64
musculature of body	2.27e-21	64
epithelial vesicle	3.92e-21	78
mesenchyme	2.28e-20	160
entire embryonic mesenchyme	2.28e-20	160
splanchnic layer of lateral plate mesoderm	3.98e-20	83
circulatory system	5.81e-20	112
trunk mesenchyme	1.40e-19	122
cardiovascular system	1.99e-18	109
primary circulatory organ	3.73e-18	27
multi-tissue structure	3.04e-17	342
organism subdivision	7.45e-17	264
trunk	1.95e-16	199
heart	2.68e-16	24
primitive heart tube	2.68e-16	24
primary heart field	2.68e-16	24
anterior lateral plate mesoderm	2.68e-16	24
heart tube	2.68e-16	24
heart primordium	2.68e-16	24
cardiac mesoderm	2.68e-16	24
cardiogenic plate	2.68e-16	24
heart rudiment	2.68e-16	24
vasculature	7.10e-16	78
vascular system	7.10e-16	78
unilaminar epithelium	9.67e-15	148
epithelial tube	2.76e-14	117
systemic artery	3.82e-14	33
systemic arterial system	3.82e-14	33
artery	1.02e-13	42
arterial blood vessel	1.02e-13	42
arterial system	1.02e-13	42
cell layer	1.67e-13	309
vessel	2.10e-13	68
epithelium	5.80e-13	306
anatomical cluster	1.72e-12	373
epithelial tube open at both ends	4.21e-12	59
blood vessel	4.21e-12	59
blood vasculature	4.21e-12	59
vascular cord	4.21e-12	59
multi-cellular organism	5.00e-12	656
compound organ	3.76e-11	68
anatomical system	6.41e-11	624
anatomical group	9.34e-11	625
anatomical conduit	1.21e-09	240
mesoderm	9.55e-09	315
mesoderm-derived structure	9.55e-09	315
presumptive mesoderm	9.55e-09	315
blood vessel smooth muscle	1.02e-07	10
arterial system smooth muscle	1.02e-07	10
artery smooth muscle tissue	1.02e-07	10
aorta smooth muscle tissue	1.02e-07	10
primordium	1.95e-07	160
smooth muscle tissue	2.61e-07	15

Disease

Ontology term	p-value	n
ovarian cancer	6.92e-09	14

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

---

Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

---

(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
ZNF263#10127	3	8.22184163701068	0.00179904392556587	0.0109333924086223

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

---

This analysis result is provided for C0 - C305 clusters.