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Coexpression cluster:C3694

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Full id: C3694_Cardiac_Smooth_Mesenchymal_mesenchymal_Hair_heart_Fibroblast



Phase1 CAGE Peaks

Hg19::chr17:77020146..77020158,+p7@C1QTNF1
Hg19::chr17:77020171..77020195,+p3@C1QTNF1
Hg19::chr17:77020477..77020492,+p6@C1QTNF1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
multilaminar epithelium3.64e-2683
somite1.68e-2471
presomitic mesoderm1.68e-2471
presumptive segmental plate1.68e-2471
dermomyotome1.68e-2471
trunk paraxial mesoderm1.68e-2471
paraxial mesoderm2.24e-2472
presumptive paraxial mesoderm2.24e-2472
dense mesenchyme tissue1.26e-2373
skeletal muscle tissue3.59e-2262
striated muscle tissue3.59e-2262
myotome3.59e-2262
muscle tissue2.27e-2164
musculature2.27e-2164
musculature of body2.27e-2164
epithelial vesicle3.92e-2178
mesenchyme2.28e-20160
entire embryonic mesenchyme2.28e-20160
splanchnic layer of lateral plate mesoderm3.98e-2083
circulatory system5.81e-20112
trunk mesenchyme1.40e-19122
cardiovascular system1.99e-18109
primary circulatory organ3.73e-1827
multi-tissue structure3.04e-17342
organism subdivision7.45e-17264
trunk1.95e-16199
heart2.68e-1624
primitive heart tube2.68e-1624
primary heart field2.68e-1624
anterior lateral plate mesoderm2.68e-1624
heart tube2.68e-1624
heart primordium2.68e-1624
cardiac mesoderm2.68e-1624
cardiogenic plate2.68e-1624
heart rudiment2.68e-1624
vasculature7.10e-1678
vascular system7.10e-1678
unilaminar epithelium9.67e-15148
epithelial tube2.76e-14117
systemic artery3.82e-1433
systemic arterial system3.82e-1433
artery1.02e-1342
arterial blood vessel1.02e-1342
arterial system1.02e-1342
cell layer1.67e-13309
vessel2.10e-1368
epithelium5.80e-13306
anatomical cluster1.72e-12373
epithelial tube open at both ends4.21e-1259
blood vessel4.21e-1259
blood vasculature4.21e-1259
vascular cord4.21e-1259
multi-cellular organism5.00e-12656
compound organ3.76e-1168
anatomical system6.41e-11624
anatomical group9.34e-11625
anatomical conduit1.21e-09240
mesoderm9.55e-09315
mesoderm-derived structure9.55e-09315
presumptive mesoderm9.55e-09315
blood vessel smooth muscle1.02e-0710
arterial system smooth muscle1.02e-0710
artery smooth muscle tissue1.02e-0710
aorta smooth muscle tissue1.02e-0710
primordium1.95e-07160
smooth muscle tissue2.61e-0715
Disease
Ontology termp-valuen
ovarian cancer6.92e-0914


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
ZNF263#1012738.221841637010680.001799043925565870.0109333924086223



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.