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Coexpression cluster:C1977

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Full id: C1977_peripheral_occipital_parietal_temporal_neuroblastoma_amygdala_brain



Phase1 CAGE Peaks

  Short description
Hg19::chr6:40555143..40555161,- p2@LRFN2
Hg19::chr8:56014575..56014610,+ p2@XKR4
Hg19::chr8:56014644..56014710,+ p1@XKR4
Hg19::chr8:56015008..56015048,+ p3@XKR4
Hg19::chr8:56025147..56025152,+ p@chr8:56025147..56025152
+


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
embryonic stem cell3.65e-075
neuronal stem cell7.26e-078
Uber Anatomy
Ontology termp-valuen
central nervous system1.95e-6481
nervous system1.77e-6089
neural tube1.82e-5956
neural rod1.82e-5956
future spinal cord1.82e-5956
neural keel1.82e-5956
neurectoderm1.24e-5886
neural plate2.44e-5582
presumptive neural plate2.44e-5582
regional part of nervous system3.83e-5553
regional part of brain3.83e-5553
brain9.25e-5268
future brain9.25e-5268
regional part of forebrain4.98e-4941
forebrain4.98e-4941
anterior neural tube4.98e-4941
future forebrain4.98e-4941
pre-chordal neural plate2.66e-4561
adult organism5.70e-44114
brain grey matter5.42e-4234
gray matter5.42e-4234
telencephalon1.31e-4134
ecto-epithelium1.80e-41104
ectoderm-derived structure2.29e-40171
ectoderm2.29e-40171
presumptive ectoderm2.29e-40171
cerebral hemisphere1.72e-3932
regional part of telencephalon3.65e-3932
regional part of cerebral cortex2.24e-3422
structure with developmental contribution from neural crest1.43e-33132
cerebral cortex3.77e-3225
pallium3.77e-3225
neocortex2.33e-3120
organ system subdivision2.69e-28223
anatomical cluster2.37e-19373
organ part7.12e-13218
tube1.27e-12192
embryo2.06e-12592
multi-tissue structure1.09e-11342
posterior neural tube1.18e-1115
chordal neural plate1.18e-1115
basal ganglion1.80e-119
nuclear complex of neuraxis1.80e-119
aggregate regional part of brain1.80e-119
collection of basal ganglia1.80e-119
cerebral subcortex1.80e-119
neural nucleus3.77e-119
nucleus of brain3.77e-119
gyrus5.43e-116
occipital lobe1.59e-095
temporal lobe1.89e-096
developing anatomical structure2.03e-09581
limbic system2.84e-095
parietal lobe3.20e-095
multi-cellular organism9.73e-09656
diencephalon1.11e-087
future diencephalon1.11e-087
organ1.79e-08503
telencephalic nucleus1.89e-087
epithelium2.45e-08306
embryonic structure3.51e-08564
anatomical conduit3.68e-08240
cell layer4.28e-08309
segmental subdivision of hindbrain5.47e-0812
hindbrain5.47e-0812
presumptive hindbrain5.47e-0812
germ layer5.73e-08560
germ layer / neural crest5.73e-08560
embryonic tissue5.73e-08560
presumptive structure5.73e-08560
germ layer / neural crest derived structure5.73e-08560
epiblast (generic)5.73e-08560
corpus striatum1.43e-074
striatum1.43e-074
ventral part of telencephalon1.43e-074
future corpus striatum1.43e-074
atypical epithelium1.78e-074
segmental subdivision of nervous system3.03e-0713


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.12.24383
MA0004.10.626788
MA0006.11.14863
MA0007.10.606704
MA0009.11.11255
MA0014.10.660087
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.569896
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.15.68117
MA0056.10
MA0057.11.05691
MA0058.10.523638
MA0059.10.522232
MA0060.10.321781
MA0061.10.791444
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.12.92967
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.11.2972
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.412364
MA0089.10
MA0090.12.34702
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.11.00065
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.143698
MA0146.10.0359558
MA0147.10.386018
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.15493
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.425004
MA0065.20.146576
MA0150.10.550239
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.514087
MA0155.10.130813
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.11.72541
MA0163.13.1409
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.22.79313
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
JUN#372537.50769751540180.004511206552906030.0213381295823801
REST#597835.790017229676810.009468788694433940.0357059078010538
ZNF263#1012746.577473309608540.0009875103237900160.00709511493576675



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.