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Coexpression cluster:C2777

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Full id: C2777_medulloblastoma_occipital_temporal_parietal_duodenum_neuroblastoma_Neurons



Phase1 CAGE Peaks

  Short description
Hg19::chr4:140478299..140478335,- p5@SETD7
Hg19::chr4:186877481..186877494,- p18@SORBS2
Hg19::chr9:103791052..103791084,+ p3@LPPR1
Hg19::chr9:103791098..103791109,+ p9@LPPR1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0018024histone-lysine N-methyltransferase activity0.0181391123449527
GO:0016278lysine N-methyltransferase activity0.0181391123449527
GO:0016279protein-lysine N-methyltransferase activity0.0181391123449527
GO:0042054histone methyltransferase activity0.0181391123449527
GO:0008276protein methyltransferase activity0.0181391123449527
GO:0008170N-methyltransferase activity0.0181391123449527
GO:0008757S-adenosylmethionine-dependent methyltransferase activity0.0267280542339939



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
neuronal stem cell4.60e-078
Uber Anatomy
Ontology termp-valuen
nervous system1.53e-6389
central nervous system1.97e-6381
neural tube3.26e-6156
neural rod3.26e-6156
future spinal cord3.26e-6156
neural keel3.26e-6156
regional part of nervous system4.37e-5753
regional part of brain4.37e-5753
regional part of forebrain8.82e-5341
forebrain8.82e-5341
anterior neural tube8.82e-5341
future forebrain8.82e-5341
brain5.92e-5168
future brain5.92e-5168
neural plate2.03e-4882
presumptive neural plate2.03e-4882
neurectoderm5.12e-4786
telencephalon4.91e-4634
brain grey matter5.78e-4634
gray matter5.78e-4634
cerebral hemisphere1.52e-4332
regional part of telencephalon2.16e-4332
pre-chordal neural plate3.85e-4061
ecto-epithelium8.97e-39104
adult organism1.46e-37114
cerebral cortex6.56e-3425
pallium6.56e-3425
ectoderm-derived structure2.75e-33171
ectoderm2.75e-33171
presumptive ectoderm2.75e-33171
organ system subdivision4.90e-32223
regional part of cerebral cortex9.98e-3122
neocortex3.04e-2820
structure with developmental contribution from neural crest2.53e-27132
tube4.61e-18192
anatomical cluster4.65e-17373
basal ganglion1.01e-139
nuclear complex of neuraxis1.01e-139
aggregate regional part of brain1.01e-139
collection of basal ganglia1.01e-139
cerebral subcortex1.01e-139
anatomical conduit1.87e-13240
neural nucleus2.66e-139
nucleus of brain2.66e-139
telencephalic nucleus7.65e-117
posterior neural tube2.79e-1015
chordal neural plate2.79e-1015
epithelium2.80e-10306
cell layer5.55e-10309
gyrus6.39e-106
embryo2.02e-09592
brainstem4.42e-096
parietal lobe6.25e-095
temporal lobe1.29e-086
occipital lobe1.88e-085
limbic system1.96e-085
diencephalon4.14e-087
future diencephalon4.14e-087
germ layer4.33e-08560
germ layer / neural crest4.33e-08560
embryonic tissue4.33e-08560
presumptive structure4.33e-08560
germ layer / neural crest derived structure4.33e-08560
epiblast (generic)4.33e-08560
segmental subdivision of nervous system5.25e-0813
multi-tissue structure6.56e-08342
embryonic structure7.91e-08564
developing anatomical structure1.74e-07581
corpus striatum1.80e-074
striatum1.80e-074
ventral part of telencephalon1.80e-074
future corpus striatum1.80e-074
regional part of diencephalon4.30e-074
multi-cellular organism5.42e-07656
segmental subdivision of hindbrain6.51e-0712
hindbrain6.51e-0712
presumptive hindbrain6.51e-0712


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.233555
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.524262
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.11.66514
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.10.69331
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.946082
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.11.19071
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.0343867
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.536981
MA0089.10
MA0090.10.640115
MA0091.10.715356
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.11.33363
MA0103.10.521546
MA0105.12.66951
MA0106.10.869173
MA0107.12.98058
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.11.63368
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.195821
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.20.778873
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.21.37305
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.577908
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.180766
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.640035
MA0163.10.253219
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.21.11128
MA0102.21.75932
MA0258.10.418966
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOXA1#316938.311064812039090.002740138182109850.0150405892469317
FOXA2#3170212.31523187633260.009361916285467240.0353514055585333



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.