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{{Coexpression_clusters
{{Coexpression_clusters
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|full_id=C849_papillotubular_lung_mucinous_oral_Renal_clear_gall
|full_id=C849_papillotubular_lung_mucinous_oral_Renal_clear_gall
|id=C849
|id=C849

Revision as of 18:36, 12 September 2012


Full id: C849_papillotubular_lung_mucinous_oral_Renal_clear_gall



Phase1 CAGE Peaks

Hg19::chr19:51471362..51471380,-p7@KLK6
Hg19::chr19:51471381..51471383,-p14@KLK6
Hg19::chr19:51471909..51471917,-p10@KLK6
Hg19::chr19:51471925..51471946,-p4@KLK6
Hg19::chr19:51471965..51471976,-p5@KLK6
Hg19::chr19:51472031..51472042,-p6@KLK6
Hg19::chr19:51472081..51472088,-p8@KLK6
Hg19::chr19:51472185..51472197,-p11@KLK6
Hg19::chr19:51472222..51472234,-p9@KLK6
Hg19::chr8:143317560..143317581,-p@chr8:143317560..143317581
-


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br>disease_data<br>


Cell Type
Ontology termp-valuen
epithelial cell1.01e-16254
kidney tubule cell1.63e-0712
nephron tubule epithelial cell1.63e-0712
epithelial cell of nephron4.28e-0716
kidney cell5.16e-0718
kidney epithelial cell5.16e-0718
Uber Anatomy
Ontology termp-valuen
adult organism2.41e-15115
neural tube1.09e-1457
neural rod1.09e-1457
future spinal cord1.09e-1457
neural keel1.09e-1457
anatomical cavity2.72e-1370
organ2.98e-13511
body cavity precursor3.69e-1263
central nervous system4.55e-1282
cavitated compound organ1.24e-1132
anatomical space1.90e-11104
anatomical cluster9.54e-11286
organ part1.14e-10219
regional part of brain1.23e-1059
embryo2.26e-10612
immaterial anatomical entity2.40e-10126
brain2.67e-1069
future brain2.67e-1069
anatomical conduit3.10e-10241
duct3.71e-1026
ectoderm-derived structure8.15e-10169
anterior neural tube1.55e-0942
regional part of nervous system1.78e-0994
nervous system1.78e-0994
intraembryonic coelom2.65e-0921
trunk region element2.77e-09107
kidney3.08e-0927
kidney mesenchyme3.08e-0927
kidney rudiment3.08e-0927
kidney field3.08e-0927
ectoderm3.48e-09173
presumptive ectoderm3.48e-09173
regional part of forebrain5.13e-0941
forebrain5.13e-0941
future forebrain5.13e-0941
mixed endoderm/mesoderm-derived structure6.94e-09130
gray matter8.30e-0934
brain grey matter8.30e-0934
telencephalon1.02e-0834
organism subdivision1.28e-08365
embryonic structure1.39e-08605
developing anatomical structure1.39e-08605
brainstem2.02e-088
tube2.27e-08194
foregut2.34e-0898
mesonephros2.88e-0818
pronephros2.88e-0818
nephrogenic cord2.88e-0818
pronephric mesoderm2.88e-0818
rostral part of nephrogenic cord2.88e-0818
presumptive pronephric mesoderm2.88e-0818
nucleus of brain3.16e-089
neural nucleus3.16e-089
neural plate3.18e-0886
presumptive neural plate3.18e-0886
germ layer3.28e-08604
embryonic tissue3.28e-08604
presumptive structure3.28e-08604
epiblast (generic)3.28e-08604
regional part of telencephalon3.54e-0833
head3.62e-08123
anterior region of body4.84e-08129
craniocervical region4.84e-08129
multi-cellular organism6.02e-08659
excretory tube9.86e-0817
mesonephric epithelium9.86e-0817
mesonephric tubule9.86e-0817
nephric duct9.86e-0817
kidney epithelium9.86e-0817
renal duct9.86e-0817
mesonephric duct9.86e-0817
pronephric duct9.86e-0817
multi-tissue structure1.53e-07347
renal tubule1.63e-0712
nephron tubule1.63e-0712
nephron tubule epithelium1.63e-0712
neurectoderm2.14e-0790
cerebral hemisphere2.48e-0732
urinary system structure2.56e-0744
abdomen element2.88e-0755
abdominal segment element2.88e-0755
digestive system3.06e-07155
digestive tract3.06e-07155
primitive gut3.06e-07155
subdivision of digestive tract4.16e-07129
endodermal part of digestive tract4.16e-07129
nephron epithelium4.28e-0716
nephron4.28e-0716
uriniferous tubule4.28e-0716
metanephric mesenchyme4.28e-0716
nephrogenic mesenchyme4.28e-0716
urogenital ridge4.72e-0720
viscus4.81e-0718

Disease
Ontology termp-valuen


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EGR1#195873.49172536636710.0008771692339228240.0065426851608103



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.