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Coexpression cluster:C4015

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Full id: C4015_spinal_neuroectodermal_optic_osteosarcoma_corpus_neuroepithelioma_thalamus



Phase1 CAGE Peaks

  Short description
Hg19::chr20:21494577..21494588,- p4@NKX2-2
Hg19::chr20:21494602..21494622,- p3@NKX2-2
Hg19::chr20:21494654..21494678,- p2@NKX2-2


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
neural tube8.71e-8056
neural rod8.71e-8056
future spinal cord8.71e-8056
neural keel8.71e-8056
regional part of nervous system9.95e-7353
regional part of brain9.95e-7353
brain6.22e-7168
future brain6.22e-7168
central nervous system1.53e-6981
nervous system2.81e-6789
regional part of forebrain1.19e-5741
forebrain1.19e-5741
anterior neural tube1.19e-5741
future forebrain1.19e-5741
telencephalon1.72e-5734
brain grey matter3.10e-5734
gray matter3.10e-5734
neurectoderm1.45e-5586
neural plate1.84e-5382
presumptive neural plate1.84e-5382
regional part of telencephalon1.21e-5232
cerebral hemisphere1.31e-5232
ecto-epithelium1.90e-43104
regional part of cerebral cortex9.35e-3922
pre-chordal neural plate1.60e-3861
cerebral cortex6.11e-3725
pallium6.11e-3725
ectoderm-derived structure1.02e-35171
ectoderm1.02e-35171
presumptive ectoderm1.02e-35171
neocortex1.32e-3420
adult organism6.62e-34114
structure with developmental contribution from neural crest2.99e-33132
organ system subdivision8.78e-25223
posterior neural tube3.60e-2215
chordal neural plate3.60e-2215
neural nucleus3.64e-229
nucleus of brain3.64e-229
basal ganglion7.46e-229
nuclear complex of neuraxis7.46e-229
aggregate regional part of brain7.46e-229
collection of basal ganglia7.46e-229
cerebral subcortex7.46e-229
segmental subdivision of nervous system6.49e-1813
telencephalic nucleus1.31e-177
tube2.43e-17192
brainstem1.00e-156
segmental subdivision of hindbrain1.29e-1512
hindbrain1.29e-1512
presumptive hindbrain1.29e-1512
gyrus9.35e-156
anatomical conduit7.33e-13240
parietal lobe7.88e-135
limbic system3.31e-125
anatomical cluster2.67e-11373
corpus striatum2.23e-104
striatum2.23e-104
ventral part of telencephalon2.23e-104
future corpus striatum2.23e-104
organ part1.06e-09218
regional part of metencephalon2.26e-099
metencephalon2.26e-099
future metencephalon2.26e-099
organ6.42e-09503
temporal lobe7.02e-096
epithelium9.93e-09306
medulla oblongata9.93e-093
myelencephalon9.93e-093
future myelencephalon9.93e-093
spinal cord1.05e-083
dorsal region element1.05e-083
dorsum1.05e-083
pons1.10e-083
cell layer1.58e-08309
occipital lobe1.78e-085
caudate-putamen3.00e-083
dorsal striatum3.00e-083
frontal cortex6.23e-083
neural tissue9.78e-072


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.11.0927
MA0004.11.93041
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.758317
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.14.3182
MA0058.11.70328
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.668628
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.18.72191
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.12.626
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.22.59836
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.13.02823
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.707589
MA0147.13.48176
MA0148.10.854239
MA0149.13.38595
MA0062.21.141
MA0035.20.894194
MA0039.20.432958
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.22.13189
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.12.08673
MA0153.11.43021
MA0154.10.312019
MA0155.10.256269
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.12.05956
MA0163.11.2663
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.26.90173
MA0102.21.88331
MA0258.10.519674
MA0259.11.40979
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
MAX#414936.452555509007120.003721913834265510.0186800403160582
SRF#6722313.79717826216780.0003806615025800190.00375516262094593
SUZ12#23512350.11578091106297.93834897779404e-060.000222869147551568
USF1#739136.361499277207960.00388404057290560.019055116187227



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.