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Coexpression cluster:C2588

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Full id: C2588_occipital_neuroblastoma_medial_parietal_pons_locus_middle



Phase1 CAGE Peaks

Hg19::chr1:50571340..50571365,+p10@ELAVL4
Hg19::chr1:50571897..50571910,+p9@ELAVL4
Hg19::chr1:50571949..50571958,+p15@ELAVL4
Hg19::chr1:50574585..50574627,+p1@ELAVL4


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube2.55e-7456
neural rod2.55e-7456
future spinal cord2.55e-7456
neural keel2.55e-7456
regional part of nervous system6.41e-7153
regional part of brain6.41e-7153
nervous system5.38e-6489
central nervous system6.20e-6281
brain grey matter2.80e-6134
gray matter2.80e-6134
telencephalon9.62e-6134
regional part of forebrain1.17e-6041
forebrain1.17e-6041
anterior neural tube1.17e-6041
future forebrain1.17e-6041
cerebral hemisphere2.01e-6032
regional part of cerebral cortex1.31e-5922
brain1.15e-5868
future brain1.15e-5868
cerebral cortex1.18e-5625
pallium1.18e-5625
regional part of telencephalon1.25e-5532
neocortex2.76e-5420
neural plate3.31e-5082
presumptive neural plate3.31e-5082
neurectoderm2.17e-4786
pre-chordal neural plate6.54e-4161
ecto-epithelium1.23e-39104
adult organism2.81e-35114
ectoderm-derived structure1.26e-32171
ectoderm1.26e-32171
presumptive ectoderm1.26e-32171
organ system subdivision4.60e-31223
structure with developmental contribution from neural crest6.54e-29132
gyrus3.46e-196
brainstem2.27e-186
parietal lobe7.38e-165
tube1.40e-15192
temporal lobe2.84e-156
occipital lobe5.14e-155
limbic system7.97e-155
posterior neural tube1.26e-1415
chordal neural plate1.26e-1415
anatomical cluster5.00e-14373
segmental subdivision of hindbrain1.52e-1112
hindbrain1.52e-1112
presumptive hindbrain1.52e-1112
anatomical conduit3.32e-11240
organ part6.11e-11218
frontal cortex1.39e-103
segmental subdivision of nervous system1.43e-1013
pons1.58e-103
medulla oblongata1.43e-093
myelencephalon1.43e-093
future myelencephalon1.43e-093
small intestine3.58e-094
multi-tissue structure9.22e-09342
neural nucleus3.74e-089
nucleus of brain3.74e-089
basal ganglion8.16e-089
nuclear complex of neuraxis8.16e-089
aggregate regional part of brain8.16e-089
collection of basal ganglia8.16e-089
cerebral subcortex8.16e-089
middle frontal gyrus1.15e-072
middle temporal gyrus1.34e-072
locus ceruleus1.72e-072
brainstem nucleus1.72e-072
hindbrain nucleus1.72e-072
embryo2.29e-07592
epithelium2.58e-07306
embryonic structure2.72e-07564
cell layer3.76e-07309
germ layer6.81e-07560
germ layer / neural crest6.81e-07560
embryonic tissue6.81e-07560
presumptive structure6.81e-07560
germ layer / neural crest derived structure6.81e-07560
epiblast (generic)6.81e-07560
Ammon's horn6.97e-072
lobe parts of cerebral cortex6.97e-072
hippocampal formation6.97e-072
limbic lobe6.97e-072
amygdala8.08e-072


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0214529
MA0004.10.71247
MA0006.10.532262
MA0007.10.6918
MA0009.11.20602
MA0014.10.0695829
MA0017.10.577281
MA0019.10.873355
MA0024.11.09684
MA0025.11.34373
MA0027.12.83281
MA0028.10.550763
MA0029.11.11704
MA0030.11.10506
MA0031.11.03735
MA0038.10.824639
MA0040.11.12314
MA0041.10.732902
MA0042.10.697662
MA0043.11.20635
MA0046.11.19471
MA0048.10.25531
MA0050.10.69864
MA0051.10.820063
MA0052.11.12718
MA0055.10.396851
MA0056.10
MA0057.10.248209
MA0058.10.605914
MA0059.10.604454
MA0060.10.393285
MA0061.10.360128
MA0063.10
MA0066.10.825101
MA0067.11.53181
MA0068.10.313194
MA0069.12.67291
MA0070.11.17908
MA0071.10.782546
MA0072.11.1744
MA0073.10.100363
MA0074.10.819248
MA0076.10.623864
MA0077.11.16637
MA0078.10.926725
MA0081.10.604638
MA0083.11.21381
MA0084.11.72172
MA0087.11.17185
MA0088.10.182167
MA0089.10
MA0090.10.640115
MA0091.11.70187
MA0092.10.673508
MA0093.10.535768
MA0095.10
MA0098.10
MA0100.10.83965
MA0101.10.539569
MA0103.10.521546
MA0105.10.232357
MA0106.10.869173
MA0107.10.453492
MA0108.21.03412
MA0109.10
MA0111.10.655276
MA0113.10.886811
MA0114.10.447443
MA0115.11.45393
MA0116.10.457606
MA0117.11.24497
MA0119.10.586221
MA0122.11.27173
MA0124.11.41151
MA0125.11.32534
MA0130.10
MA0131.10.94608
MA0132.10
MA0133.10
MA0135.11.23748
MA0136.10.832277
MA0139.10.344952
MA0140.10.779643
MA0141.10.602484
MA0142.11.00381
MA0143.10.887001
MA0144.10.430413
MA0145.10.569905
MA0146.10.061409
MA0147.10.46175
MA0148.10.739888
MA0149.10.769072
MA0062.20.353589
MA0035.21.83323
MA0039.20.0247757
MA0138.20.928035
MA0002.20.379056
MA0137.20.558189
MA0104.20.392359
MA0047.20.856092
MA0112.20.187982
MA0065.20.199162
MA0150.10.633493
MA0151.10
MA0152.10.78681
MA0153.11.30799
MA0154.10.229241
MA0155.10.533581
MA0156.10.560797
MA0157.10.97481
MA0158.10
MA0159.10.462502
MA0160.10.756582
MA0161.10
MA0162.10.0928415
MA0163.10.0725493
MA0164.10.90014
MA0080.20.535868
MA0018.20.870662
MA0099.20.7872
MA0079.20.00910927
MA0102.21.75932
MA0258.11.07498
MA0259.10.471671
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
EP300#203335.08045629466740.01144298405398240.0419007717415983
GATA2#262439.55869880016550.001818151618357440.0109023331727412



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.