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Coexpression cluster:C3177: Difference between revisions

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|tf_chipseq_enrich=SPI1#6688;3:8.20432350852273:0.00181059318941052:0.0108826278837963
|tf_chipseq_enrich=SPI1#6688;3:8.20432350852273:0.00181059318941052:0.0108826278837963
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}}
}}

Revision as of 15:58, 26 November 2012


Full id: C3177_substantia_optic_Adipocyte_diencephalon_locus_globus_spinal



Phase1 CAGE Peaks

Hg19::chr11:63339842..63339883,-p@chr11:63339842..63339883
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Hg19::chr11:63339884..63339902,-p@chr11:63339884..63339902
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Hg19::chr11:63339983..63340004,-p@chr11:63339983..63340004
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Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br>disease_data<br>


Uber Anatomy
Ontology termp-valuen
adult organism7.58e-33114
neural tube1.60e-2756
neural rod1.60e-2756
future spinal cord1.60e-2756
neural keel1.60e-2756
regional part of nervous system4.27e-2553
regional part of brain4.27e-2553
central nervous system1.51e-2381
nervous system4.96e-2289
regional part of forebrain7.27e-2241
forebrain7.27e-2241
anterior neural tube7.27e-2241
future forebrain7.27e-2241
brain3.47e-2168
future brain3.47e-2168
neural plate7.57e-1982
presumptive neural plate7.57e-1982
brain grey matter1.12e-1734
gray matter1.12e-1734
telencephalon3.31e-1734
neurectoderm6.49e-1786
organ system subdivision8.00e-17223
regional part of telencephalon4.85e-1632
cerebral hemisphere1.14e-1532
structure with developmental contribution from neural crest2.81e-15132
pre-chordal neural plate3.64e-1461
ecto-epithelium1.39e-12104
cerebral cortex5.18e-1125
pallium5.18e-1125
anatomical cluster5.33e-10373
regional part of cerebral cortex9.31e-1022
ectoderm-derived structure8.04e-09171
ectoderm8.04e-09171
presumptive ectoderm8.04e-09171
neural nucleus1.09e-089
nucleus of brain1.09e-089
tube1.35e-08192
basal ganglion1.69e-089
nuclear complex of neuraxis1.69e-089
aggregate regional part of brain1.69e-089
collection of basal ganglia1.69e-089
cerebral subcortex1.69e-089
organ part2.03e-08218
neocortex2.91e-0820
multi-tissue structure5.80e-08342
anatomical conduit1.39e-07240
telencephalic nucleus5.92e-077
posterior neural tube6.44e-0715
chordal neural plate6.44e-0715
Disease
Ontology termp-valuen
carcinoma1.56e-07106
cell type cancer2.85e-07143


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
SPI1#668838.204323508522730.001810593189410520.0108826278837963



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.