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Coexpression cluster:C795

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Full id: C795_occipital_postcentral_Whole_temporal_paracentral_insula_parietal



Phase1 CAGE Peaks

Hg19::chr11:124609823..124609869,+p1@NRGN
Hg19::chr11:124615457..124615462,+p@chr11:124615457..124615462
+
Hg19::chr11:124615557..124615575,+p@chr11:124615557..124615575
+
Hg19::chr11:124616356..124616367,-p6@ENST00000531241
Hg19::chr11:124616378..124616428,-p2@ENST00000531241
Hg19::chr11:124616466..124616477,-p8@ENST00000531241
Hg19::chr11:124616487..124616565,-p1@ENST00000531241
Hg19::chr11:124616678..124616697,-p10@ENST00000531241
Hg19::chr11:124616843..124616873,-p@chr11:124616843..124616873
-
Hg19::chr16:2564254..2564305,+p@chr16:2564254..2564305
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005516calmodulin binding0.0415047686329919



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
classical monocyte5.10e-0842
CD14-positive, CD16-negative classical monocyte5.10e-0842
monopoietic cell9.72e-0859
monocyte9.72e-0859
monoblast9.72e-0859
promonocyte9.72e-0859
macrophage dendritic cell progenitor2.69e-0761
defensive cell2.74e-0748
phagocyte2.74e-0748
Uber Anatomy
Ontology termp-valuen
telencephalon1.17e-2934
cerebral hemisphere1.22e-2932
regional part of forebrain2.59e-2741
forebrain2.59e-2741
anterior neural tube2.59e-2741
future forebrain2.59e-2741
brain grey matter5.05e-2734
gray matter5.05e-2734
regional part of telencephalon5.37e-2732
regional part of cerebral cortex8.92e-2422
regional part of nervous system1.57e-2353
regional part of brain1.57e-2353
adult organism1.77e-23114
neural tube2.60e-2356
neural rod2.60e-2356
future spinal cord2.60e-2356
neural keel2.60e-2356
neocortex4.58e-2120
cerebral cortex2.87e-2025
pallium2.87e-2025
brain5.30e-2068
future brain5.30e-2068
central nervous system1.25e-1981
nervous system1.62e-1889
pre-chordal neural plate1.07e-1761
neurectoderm2.84e-1686
neural plate1.70e-1582
presumptive neural plate1.70e-1582
blood2.07e-1415
haemolymphatic fluid2.07e-1415
organism substance2.07e-1415
hematopoietic system1.06e-1198
blood island1.06e-1198
basal ganglion3.90e-119
nuclear complex of neuraxis3.90e-119
aggregate regional part of brain3.90e-119
collection of basal ganglia3.90e-119
cerebral subcortex3.90e-119
ecto-epithelium8.38e-11104
gyrus8.50e-116
hemolymphoid system2.23e-10108
limbic system6.67e-095
temporal lobe8.15e-096
telencephalic nucleus2.76e-087
neural nucleus3.58e-089
nucleus of brain3.58e-089
structure with developmental contribution from neural crest4.06e-08132
germ layer6.45e-08560
germ layer / neural crest6.45e-08560
embryonic tissue6.45e-08560
presumptive structure6.45e-08560
germ layer / neural crest derived structure6.45e-08560
epiblast (generic)6.45e-08560
developing anatomical structure8.46e-08581
embryonic structure1.15e-07564
corpus striatum1.55e-074
striatum1.55e-074
ventral part of telencephalon1.55e-074
future corpus striatum1.55e-074
ectoderm-derived structure3.30e-07171
ectoderm3.30e-07171
presumptive ectoderm3.30e-07171
embryo3.92e-07592
tube5.33e-07192


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488850.17360027146251.81009809364417e-132.75575560936011e-11
CTCF#1066463.216153823845020.004429095326154860.0209696852426804
EGR1#195873.49172536636710.0008771692339228240.00654221792627764
ELF1#199772.980668571165280.002378202870469130.0134723980033047
JUND#372764.196798365122620.001065203456546050.00752392694428604
RAD21#588555.177516947728160.001393960115380.00907177221399378
SMC3#912669.02695970695971.43128844366218e-050.00034229982543539
SP1#666763.419028826884540.003207339839120720.0168217428543127
YY1#752862.946702449912310.006987247873951880.029538197964285
ZNF143#770256.750438276113950.0004088269908565020.00389788954702047



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.