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Coexpression cluster:C3393

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Full id: C3393_hereditary_caudate_parietal_breast_locus_putamen_pons



Phase1 CAGE Peaks

  Short description
Hg19::chr14:100485771..100485833,+ p4@EVL
Hg19::chr14:100485908..100485924,+ p25@EVL
Hg19::chr14:100485927..100485938,+ p29@EVL


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
neural tube1.99e-5656
neural rod1.99e-5656
future spinal cord1.99e-5656
neural keel1.99e-5656
neural plate1.32e-5182
presumptive neural plate1.32e-5182
regional part of nervous system1.34e-5153
regional part of brain1.34e-5153
neurectoderm1.36e-5086
regional part of forebrain3.41e-4741
forebrain3.41e-4741
anterior neural tube3.41e-4741
future forebrain3.41e-4741
pre-chordal neural plate1.57e-4461
central nervous system4.92e-4381
brain grey matter1.16e-4234
gray matter1.16e-4234
telencephalon3.50e-4234
nervous system6.95e-4189
brain1.47e-4068
future brain1.47e-4068
cerebral hemisphere2.03e-3932
regional part of telencephalon2.80e-3932
ecto-epithelium3.84e-37104
adult organism4.83e-37114
neocortex7.55e-3320
regional part of cerebral cortex1.45e-3222
structure with developmental contribution from neural crest1.03e-30132
cerebral cortex5.45e-2825
pallium5.45e-2825
organ system subdivision5.19e-26223
ectoderm-derived structure2.63e-24171
ectoderm2.63e-24171
presumptive ectoderm2.63e-24171
epithelium1.33e-17306
multi-tissue structure1.89e-17342
tube2.67e-17192
cell layer3.20e-17309
anatomical cluster1.16e-16373
organ part1.23e-16218
neural nucleus1.94e-169
nucleus of brain1.94e-169
telencephalic nucleus4.53e-137
basal ganglion9.46e-139
nuclear complex of neuraxis9.46e-139
aggregate regional part of brain9.46e-139
collection of basal ganglia9.46e-139
cerebral subcortex9.46e-139
gyrus1.32e-116
brainstem1.96e-116
anatomical conduit2.41e-11240
posterior neural tube1.22e-1015
chordal neural plate1.22e-1015
parietal lobe3.75e-105
occipital lobe4.95e-105
temporal lobe7.61e-106
embryo4.17e-09592
corpus striatum6.77e-094
striatum6.77e-094
ventral part of telencephalon6.77e-094
future corpus striatum6.77e-094
organ8.91e-09503
germ layer1.20e-08560
germ layer / neural crest1.20e-08560
embryonic tissue1.20e-08560
presumptive structure1.20e-08560
germ layer / neural crest derived structure1.20e-08560
epiblast (generic)1.20e-08560
embryonic structure2.07e-08564
developing anatomical structure2.56e-08581
multi-cellular organism3.70e-08656
segmental subdivision of nervous system4.08e-0813
intestine7.22e-0817
layer of retina1.24e-074
retina2.64e-076
photoreceptor array2.64e-076
posterior segment of eyeball2.64e-076
caudate-putamen2.91e-073
dorsal striatum2.91e-073
pons7.75e-073


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.904546
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.11.67416
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.211629
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.11.31954
MA0089.10
MA0090.11.77664
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.12.63873
MA0103.10.628063
MA0105.10.31555
MA0106.12.25834
MA0107.12.34614
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.11.3784
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.11.37817
MA0146.10.107247
MA0147.10.565108
MA0148.11.98824
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.195278
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.277623
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.11.31345
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.122425
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.09178
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
FOXA2#3170216.42030916844350.004810682352105480.0225818173478154
TRIM28#10155318.59052504526250.0001555969297255280.00196688304812447
USF1#739136.361499277207960.00388404057290560.0189846638926236



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.