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Coexpression cluster:C3593

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Full id: C3593_putamen_medulla_caudate_nucleus_corpus_cerebral_globus



Phase1 CAGE Peaks

Hg19::chr16:84027018..84027029,+p@chr16:84027018..84027029
+
Hg19::chr19:6217052..6217081,-p@chr19:6217052..6217081
-
Hg19::chrX:113818545..113818566,+p1@HTR2C


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


No GOStat results

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
embryonic stem cell6.81e-155
Uber Anatomy
Ontology termp-valuen
neural tube3.52e-10256
neural rod3.52e-10256
future spinal cord3.52e-10256
neural keel3.52e-10256
regional part of nervous system1.50e-9353
regional part of brain1.50e-9353
regional part of forebrain6.16e-8341
forebrain6.16e-8341
anterior neural tube6.16e-8341
future forebrain6.16e-8341
central nervous system1.32e-7381
brain2.27e-7368
future brain2.27e-7368
neural plate3.41e-7382
presumptive neural plate3.41e-7382
neurectoderm2.65e-6986
telencephalon1.67e-6734
brain grey matter2.00e-6734
gray matter2.00e-6734
nervous system2.78e-6589
cerebral hemisphere8.61e-6232
regional part of telencephalon1.63e-6132
pre-chordal neural plate7.19e-6061
ecto-epithelium1.85e-55104
regional part of cerebral cortex1.41e-5222
adult organism1.26e-49114
structure with developmental contribution from neural crest1.10e-47132
neocortex2.24e-4620
cerebral cortex7.14e-4625
pallium7.14e-4625
ectoderm-derived structure3.03e-32171
ectoderm3.03e-32171
presumptive ectoderm3.03e-32171
tube1.27e-23192
organ system subdivision2.42e-23223
basal ganglion5.19e-239
nuclear complex of neuraxis5.19e-239
aggregate regional part of brain5.19e-239
collection of basal ganglia5.19e-239
cerebral subcortex5.19e-239
neural nucleus7.12e-239
nucleus of brain7.12e-239
brainstem6.61e-206
posterior neural tube8.15e-2015
chordal neural plate8.15e-2015
gyrus5.90e-196
limbic system2.36e-175
telencephalic nucleus5.39e-177
temporal lobe6.55e-176
anatomical conduit1.01e-16240
diencephalon2.44e-167
future diencephalon2.44e-167
corpus striatum1.23e-144
striatum1.23e-144
ventral part of telencephalon1.23e-144
future corpus striatum1.23e-144
epithelium3.95e-13306
anatomical cluster4.75e-13373
cell layer6.80e-13309
segmental subdivision of hindbrain1.34e-1212
hindbrain1.34e-1212
presumptive hindbrain1.34e-1212
organ part5.27e-12218
segmental subdivision of nervous system1.52e-1113
caudate-putamen2.17e-113
dorsal striatum2.17e-113
medulla oblongata2.32e-113
myelencephalon2.32e-113
future myelencephalon2.32e-113
multi-tissue structure2.95e-11342
parietal lobe7.87e-115
occipital lobe2.11e-105
frontal cortex2.26e-103
pons2.74e-103
spinal cord3.89e-103
dorsal region element3.89e-103
dorsum3.89e-103
embryo1.62e-08592
regional part of diencephalon4.08e-084
caudate nucleus4.72e-082
future caudate nucleus4.72e-082
Ammon's horn5.78e-082
lobe parts of cerebral cortex5.78e-082
hippocampal formation5.78e-082
limbic lobe5.78e-082
amygdala7.82e-082
dorsal plus ventral thalamus9.55e-082
thalamic complex9.55e-082
locus ceruleus1.13e-072
brainstem nucleus1.13e-072
hindbrain nucleus1.13e-072
organ1.16e-07503
gland of diencephalon1.46e-074
neuroendocrine gland1.46e-074
middle temporal gyrus1.90e-072
middle frontal gyrus2.23e-072
pituitary gland5.42e-072


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.401049
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.118426
MA0017.11.64148
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.12.4146
MA0058.10.716037
MA0059.10.714521
MA0060.10.492218
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.11.84332
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.668628
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.10.31555
MA0106.10.986396
MA0107.10.556367
MA0108.21.15387
MA0109.10
MA0111.10.767139
MA0113.11.00436
MA0114.10.549955
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.752137
MA0146.10.348055
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.432958
MA0138.21.04628
MA0002.20.476938
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.20.760954
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.11.31345
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.149099
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.21.90288
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.