Coexpression cluster:C552
From FANTOM5_SSTAR
Full id: C552_medial_temporal_occipital_parietal_duodenum_brain_spinal
Phase1 CAGE Peaks
| Hg19::chr10:105048252..105048262,+ | p@chr10:105048252..105048262 + |
| Hg19::chr10:105048347..105048358,+ | p@chr10:105048347..105048358 + |
| Hg19::chr11:132289875..132289896,- | p12@OPCML |
| Hg19::chr16:7568144..7568155,+ | p@chr16:7568144..7568155 + |
| Hg19::chr17:44039779..44039792,+ | p6@MAPT |
| Hg19::chr17:44068857..44068869,+ | p8@MAPT |
| Hg19::chr2:149633261..149633270,+ | p1@AB384491 |
| Hg19::chr2:50148868..50148876,- | p32@NRXN1 |
| Hg19::chr2:55253343..55253360,- | p29@RTN4 |
| Hg19::chr3:286287..286329,+ | p@chr3:286287..286329 + |
| Hg19::chr3:383640..383650,+ | p@chr3:383640..383650 + |
| Hg19::chr5:71482490..71482501,+ | p@chr5:71482490..71482501 + |
| Hg19::chr5:71482533..71482549,+ | p@chr5:71482533..71482549 + |
| Hg19::chr5:71489693..71489706,+ | p@chr5:71489693..71489706 + |
| Hg19::chr8:80567211..80567218,+ | p9@STMN2 |
| Hg19::chr9:111911992..111912002,- | p@chr9:111911992..111912002 - |
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
No results for this coexpression
Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0030516 | regulation of axon extension | 0.00010362994502982 |
| GO:0030182 | neuron differentiation | 0.00010362994502982 |
| GO:0048675 | axon extension | 0.00010362994502982 |
| GO:0030426 | growth cone | 0.00010362994502982 |
| GO:0030427 | site of polarized growth | 0.00010362994502982 |
| GO:0048699 | generation of neurons | 0.00010362994502982 |
| GO:0022008 | neurogenesis | 0.000112726089605561 |
| GO:0050770 | regulation of axonogenesis | 0.000123735069240019 |
| GO:0050767 | regulation of neurogenesis | 0.000237741650507623 |
| GO:0007399 | nervous system development | 0.00158975368646609 |
| GO:0007409 | axonogenesis | 0.00166359731717786 |
| GO:0048667 | neuron morphogenesis during differentiation | 0.00166359731717786 |
| GO:0048812 | neurite morphogenesis | 0.00166359731717786 |
| GO:0000904 | cellular morphogenesis during differentiation | 0.00170318642141137 |
| GO:0031175 | neurite development | 0.00182484678637508 |
| GO:0048666 | neuron development | 0.00222579120033241 |
| GO:0045298 | tubulin complex | 0.00304731298129318 |
| GO:0032990 | cell part morphogenesis | 0.0031203738849544 |
| GO:0048858 | cell projection morphogenesis | 0.0031203738849544 |
| GO:0030030 | cell projection organization and biogenesis | 0.0031203738849544 |
| GO:0019987 | negative regulation of anti-apoptosis | 0.00347582725292053 |
| GO:0030517 | negative regulation of axon extension | 0.00347582725292053 |
| GO:0048468 | cell development | 0.00347582725292053 |
| GO:0050793 | regulation of developmental process | 0.00347582725292053 |
| GO:0042995 | cell projection | 0.00575468023354051 |
| GO:0045773 | positive regulation of axon extension | 0.00575468023354051 |
| GO:0050771 | negative regulation of axonogenesis | 0.00575468023354051 |
| GO:0048731 | system development | 0.00615746870355665 |
| GO:0031116 | positive regulation of microtubule polymerization | 0.0062504053506897 |
| GO:0031112 | positive regulation of microtubule polymerization or depolymerization | 0.00668206759859369 |
| GO:0031113 | regulation of microtubule polymerization | 0.00668206759859369 |
| GO:0005515 | protein binding | 0.00719152808698763 |
| GO:0048869 | cellular developmental process | 0.00720625871783252 |
| GO:0030154 | cell differentiation | 0.00720625871783252 |
| GO:0046785 | microtubule polymerization | 0.00739713234206427 |
| GO:0008038 | neuron recognition | 0.00791035634833841 |
| GO:0050768 | negative regulation of neurogenesis | 0.00795198723378637 |
| GO:0045767 | regulation of anti-apoptosis | 0.00795198723378637 |
| GO:0048856 | anatomical structure development | 0.00795198723378637 |
| GO:0050772 | positive regulation of axonogenesis | 0.00795198723378637 |
| GO:0000902 | cell morphogenesis | 0.00795198723378637 |
| GO:0032989 | cellular structure morphogenesis | 0.00795198723378637 |
| GO:0016020 | membrane | 0.00795198723378637 |
| GO:0051130 | positive regulation of cellular component organization and biogenesis | 0.00805275855365829 |
| GO:0004985 | opioid receptor activity | 0.00805275855365829 |
| GO:0050769 | positive regulation of neurogenesis | 0.00900202403800668 |
| GO:0007275 | multicellular organismal development | 0.0104480426339578 |
| GO:0017124 | SH3 domain binding | 0.0107811353522219 |
| GO:0007026 | negative regulation of microtubule depolymerization | 0.0113835384307388 |
| GO:0031114 | regulation of microtubule depolymerization | 0.0113835384307388 |
| GO:0031111 | negative regulation of microtubule polymerization or depolymerization | 0.0114425685972422 |
| GO:0007019 | microtubule depolymerization | 0.0114425685972422 |
| GO:0031110 | regulation of microtubule polymerization or depolymerization | 0.0138883244812153 |
| GO:0008034 | lipoprotein binding | 0.0138883244812153 |
| GO:0031109 | microtubule polymerization or depolymerization | 0.0150437531143522 |
| GO:0030424 | axon | 0.0156967109218176 |
| GO:0008037 | cell recognition | 0.0172315456118835 |
| GO:0051261 | protein depolymerization | 0.020489944257951 |
| GO:0008017 | microtubule binding | 0.0214525192020646 |
| GO:0022610 | biological adhesion | 0.0216605349071122 |
| GO:0007155 | cell adhesion | 0.0216605349071122 |
| GO:0051129 | negative regulation of cellular component organization and biogenesis | 0.0216605349071122 |
| GO:0030176 | integral to endoplasmic reticulum membrane | 0.0217253746280847 |
| GO:0032502 | developmental process | 0.0225500834866176 |
| GO:0030334 | regulation of cell migration | 0.0235007884009187 |
| GO:0009653 | anatomical structure morphogenesis | 0.0235007884009187 |
| GO:0031227 | intrinsic to endoplasmic reticulum membrane | 0.0235007884009187 |
| GO:0015631 | tubulin binding | 0.0254237655144738 |
| GO:0051094 | positive regulation of developmental process | 0.0254277678098717 |
| GO:0051270 | regulation of cell motility | 0.0254316124385206 |
| GO:0048523 | negative regulation of cellular process | 0.0257941112672204 |
| GO:0040012 | regulation of locomotion | 0.0257941112672204 |
| GO:0040011 | locomotion | 0.0257941112672204 |
| GO:0048519 | negative regulation of biological process | 0.0264757184329733 |
| GO:0051093 | negative regulation of developmental process | 0.0264757184329733 |
| GO:0043005 | neuron projection | 0.0272872935115342 |
| GO:0032501 | multicellular organismal process | 0.0272872935115342 |
| GO:0005200 | structural constituent of cytoskeleton | 0.0280891153272492 |
| GO:0051258 | protein polymerization | 0.0316265304462711 |
| GO:0051128 | regulation of cellular component organization and biogenesis | 0.0321914258461296 |
| GO:0000226 | microtubule cytoskeleton organization and biogenesis | 0.0324260624446285 |
| GO:0051248 | negative regulation of protein metabolic process | 0.0326548287373963 |
| GO:0048503 | GPI anchor binding | 0.038874450927321 |
| GO:0019904 | protein domain specific binding | 0.038874450927321 |
| GO:0031301 | integral to organelle membrane | 0.042017371296162 |
| GO:0001653 | peptide receptor activity | 0.0436863081765911 |
| GO:0008528 | peptide receptor activity, G-protein coupled | 0.0436863081765911 |
| GO:0031300 | intrinsic to organelle membrane | 0.0443467218518709 |
| GO:0006916 | anti-apoptosis | 0.0489890794507065 |
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>
Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.000203219 |
| MA0004.1 | 0.238283 |
| MA0006.1 | 0.124371 |
| MA0007.1 | 0.223897 |
| MA0009.1 | 0.644692 |
| MA0014.1 | 0.024058 |
| MA0017.1 | 0.45828 |
| MA0019.1 | 0.359322 |
| MA0024.1 | 0.547222 |
| MA0025.1 | 0.771296 |
| MA0027.1 | 2.23171 |
| MA0028.1 | 0.134741 |
| MA0029.1 | 0.565022 |
| MA0030.1 | 0.554453 |
| MA0031.1 | 0.495474 |
| MA0038.1 | 0.321141 |
| MA0040.1 | 0.570428 |
| MA0041.1 | 2.00914 |
| MA0042.1 | 0.646075 |
| MA0043.1 | 0.644989 |
| MA0046.1 | 0.634468 |
| MA0048.1 | 0.0786451 |
| MA0050.1 | 0.228625 |
| MA0051.1 | 0.317617 |
| MA0052.1 | 0.574006 |
| MA0055.1 | 0.0967754 |
| MA0056.1 | 0 |
| MA0057.1 | 0.0158853 |
| MA0058.1 | 0.167587 |
| MA0059.1 | 0.166682 |
| MA0060.1 | 0.0584466 |
| MA0061.1 | 0.0461955 |
| MA0063.1 | 0 |
| MA0066.1 | 0.321498 |
| MA0067.1 | 0.948938 |
| MA0068.1 | 0.128042 |
| MA0069.1 | 0.630852 |
| MA0070.1 | 0.620368 |
| MA0071.1 | 0.289163 |
| MA0072.1 | 0.616162 |
| MA0073.1 | 0.368378 |
| MA0074.1 | 0.316991 |
| MA0076.1 | 0.178863 |
| MA0077.1 | 0.608956 |
| MA0078.1 | 0.402443 |
| MA0081.1 | 0.499456 |
| MA0083.1 | 0.651755 |
| MA0084.1 | 1.13204 |
| MA0087.1 | 0.613875 |
| MA0088.1 | 0.0965118 |
| MA0089.1 | 0 |
| MA0090.1 | 0.189305 |
| MA0091.1 | 0.240316 |
| MA0092.1 | 0.211423 |
| MA0093.1 | 0.397767 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.332778 |
| MA0101.1 | 0.403202 |
| MA0103.1 | 0.377626 |
| MA0105.1 | 0.0129929 |
| MA0106.1 | 0.355999 |
| MA0107.1 | 0.0842574 |
| MA0108.2 | 0.492699 |
| MA0109.1 | 0 |
| MA0111.1 | 0.578093 |
| MA0113.1 | 0.968027 |
| MA0114.1 | 0.278245 |
| MA0115.1 | 0.874839 |
| MA0116.1 | 0.0861811 |
| MA0117.1 | 0.680135 |
| MA0119.1 | 0.471628 |
| MA0122.1 | 0.70466 |
| MA0124.1 | 0.834787 |
| MA0125.1 | 0.75419 |
| MA0130.1 | 0 |
| MA0131.1 | 0.418384 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 0.673296 |
| MA0136.1 | 0.327047 |
| MA0139.1 | 0.159457 |
| MA0140.1 | 0.286995 |
| MA0141.1 | 0.165463 |
| MA0142.1 | 0.4668 |
| MA0143.1 | 0.370225 |
| MA0144.1 | 0.0738381 |
| MA0145.1 | 0.23881 |
| MA0146.1 | 0.0055415 |
| MA0147.1 | 0.0881384 |
| MA0148.1 | 1.31921 |
| MA0149.1 | 0.279141 |
| MA0062.2 | 0.168482 |
| MA0035.2 | 0.286421 |
| MA0039.2 | 0.0116984 |
| MA0138.2 | 0.403517 |
| MA0002.2 | 0.196222 |
| MA0137.2 | 0.138998 |
| MA0104.2 | 0.0580852 |
| MA0047.2 | 0.914023 |
| MA0112.2 | 0.22067 |
| MA0065.2 | 0.667633 |
| MA0150.1 | 0.185024 |
| MA0151.1 | 0 |
| MA0152.1 | 0.292357 |
| MA0153.1 | 0.738108 |
| MA0154.1 | 0.0124644 |
| MA0155.1 | 0.204406 |
| MA0156.1 | 0.140505 |
| MA0157.1 | 0.442323 |
| MA0158.1 | 0 |
| MA0159.1 | 0.0884959 |
| MA0160.1 | 0.26995 |
| MA0161.1 | 0 |
| MA0162.1 | 0.0005964 |
| MA0163.1 | 0.00897585 |
| MA0164.1 | 0.380804 |
| MA0080.2 | 0.397909 |
| MA0018.2 | 0.357181 |
| MA0099.2 | 0.292649 |
| MA0079.2 | 7.87875e-05 |
| MA0102.2 | 1.16862 |
| MA0258.1 | 0.242841 |
| MA0259.1 | 0.0929051 |
| MA0442.1 | 0 |
ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data
No analysis results for this cluster
Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data
This analysis result is provided for C0 - C305 clusters.
