Coexpression cluster:C653

Full id: C653_cerebellum_pituitary_pineal_nonsmall_somatostatinoma_occipital_small

Phase1 CAGE Peaks

Hg19::chr11:17498348..17498431,-	p1@ABCC8
Hg19::chr17:2652834..2652899,-	p@chr17:2652834..2652899 -
Hg19::chr17:2652910..2652993,-	p@chr17:2652910..2652993 -
Hg19::chr1:39734131..39734171,+	p3@MACF1
Hg19::chr20:10199329..10199356,-	p@chr20:10199329..10199356 -
Hg19::chr20:5892121..5892131,+	p3@CHGB
Hg19::chr5:140201183..140201218,+	p1@PCDHA5
Hg19::chr7:153790099..153790127,+	p@chr7:153790099..153790127 +
Hg19::chr7:82792120..82792150,-	p3@PCLO
Hg19::chr8:104512123..104512154,+	p@chr8:104512123..104512154 +
Hg19::chr8:104512157..104512199,+	p@chr8:104512157..104512199 +
Hg19::chr8:104512807..104512822,+	p12@RIMS2
Hg19::chr8:104512831..104512852,+	p5@RIMS2

Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data

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No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data

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GO ID	GO name	FDR corrected p-value
GO:0015079	potassium ion transmembrane transporter activity	0.0412124876932546
GO:0005522	profilin binding	0.0412124876932546
GO:0016079	synaptic vesicle exocytosis	0.0412124876932546
GO:0008281	sulfonylurea receptor activity	0.0412124876932546
GO:0005509	calcium ion binding	0.0412124876932546

Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>

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Cell Type

Ontology term	p-value	n
embryonic stem cell	2.79e-07	5

Uber Anatomy

Ontology term	p-value	n
central nervous system	3.66e-71	81
nervous system	3.46e-69	89
neural tube	4.11e-68	56
neural rod	4.11e-68	56
future spinal cord	4.11e-68	56
neural keel	4.11e-68	56
regional part of nervous system	3.96e-64	53
regional part of brain	3.96e-64	53
brain	2.22e-59	68
future brain	2.22e-59	68
regional part of forebrain	5.37e-55	41
forebrain	5.37e-55	41
anterior neural tube	5.37e-55	41
future forebrain	5.37e-55	41
neural plate	4.05e-45	82
presumptive neural plate	4.05e-45	82
telencephalon	6.10e-44	34
brain grey matter	7.75e-44	34
gray matter	7.75e-44	34
neurectoderm	3.28e-42	86
cerebral hemisphere	1.43e-41	32
regional part of telencephalon	4.58e-41	32
adult organism	9.11e-41	114
pre-chordal neural plate	8.61e-37	61
regional part of cerebral cortex	3.33e-36	22
ecto-epithelium	6.18e-35	104
neocortex	2.27e-33	20
organ system subdivision	6.07e-33	223
cerebral cortex	4.42e-31	25
pallium	4.42e-31	25
ectoderm-derived structure	1.05e-30	171
ectoderm	1.05e-30	171
presumptive ectoderm	1.05e-30	171
structure with developmental contribution from neural crest	8.05e-25	132
tube	2.38e-15	192
anatomical cluster	5.10e-15	373
basal ganglion	2.27e-14	9
nuclear complex of neuraxis	2.27e-14	9
aggregate regional part of brain	2.27e-14	9
collection of basal ganglia	2.27e-14	9
cerebral subcortex	2.27e-14	9
neural nucleus	4.23e-14	9
nucleus of brain	4.23e-14	9
posterior neural tube	5.15e-14	15
chordal neural plate	5.15e-14	15
diencephalon	2.51e-12	7
future diencephalon	2.51e-12	7
temporal lobe	7.59e-12	6
telencephalic nucleus	1.97e-11	7
gyrus	5.60e-11	6
embryo	6.89e-11	592
anatomical conduit	1.42e-10	240
segmental subdivision of hindbrain	1.74e-10	12
hindbrain	1.74e-10	12
presumptive hindbrain	1.74e-10	12
brainstem	1.19e-09	6
segmental subdivision of nervous system	1.66e-09	13
parietal lobe	2.29e-09	5
occipital lobe	3.98e-09	5
limbic system	7.21e-09	5
gland of diencephalon	1.94e-08	4
neuroendocrine gland	1.94e-08	4
organ part	3.37e-08	218
corpus striatum	7.76e-08	4
striatum	7.76e-08	4
ventral part of telencephalon	7.76e-08	4
future corpus striatum	7.76e-08	4
multi-cellular organism	9.03e-08	656
regional part of diencephalon	1.00e-07	4
developing anatomical structure	1.10e-07	581
organ	1.27e-07	503
epithelium	1.64e-07	306
germ layer	2.36e-07	560
germ layer / neural crest	2.36e-07	560
embryonic tissue	2.36e-07	560
presumptive structure	2.36e-07	560
germ layer / neural crest derived structure	2.36e-07	560
epiblast (generic)	2.36e-07	560
multi-tissue structure	2.41e-07	342
cell layer	2.77e-07	309
embryonic structure	4.05e-07	564
regional part of metencephalon	5.86e-07	9
metencephalon	5.86e-07	9
future metencephalon	5.86e-07	9
anatomical system	7.54e-07	624
anatomical group	8.57e-07	625

Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data

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Novel motifs

JASPAR motifs

Motifs	-log10(p-value)
{{{tfbs_overrepresentation_jaspar}}}

ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data

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(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF	#promoters	Enrichment	p-value	q-value
REST#5978	5	3.71154950620309	0.00752035007713961	0.0310074157799599
ZNF263#10127	6	3.79469614015877	0.00258517358054671	0.0142982017464766

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data

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This analysis result is provided for C0 - C305 clusters.