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Coexpression cluster:C1844

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Full id: C1844_squamous_epidermoid_bronchioalveolar_Corneal_Alveolar_Esophageal_Urothelial



Phase1 CAGE Peaks

  Short description
Hg19::chr1:207205989..207206000,- p4@C1orf116
Hg19::chr1:207206001..207206012,- p5@C1orf116
Hg19::chr1:207206020..207206050,- p1@C1orf116
Hg19::chr1:207206095..207206121,- p2@C1orf116
Hg19::chr1:59042917..59042931,- p1@TACSTD2


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data
disease_data


Uber Anatomy
Ontology termp-valuen
endoderm-derived structure1.25e-35160
endoderm1.25e-35160
presumptive endoderm1.25e-35160
digestive system2.42e-27145
digestive tract2.42e-27145
primitive gut2.42e-27145
subdivision of digestive tract6.61e-24118
respiratory system6.92e-1874
renal system1.81e-1748
urinary system structure1.02e-1647
orifice4.97e-1636
endo-epithelium1.62e-1582
foregut8.44e-1587
epithelial bud1.14e-1237
respiratory tract7.16e-1254
trunk region element7.50e-12101
anatomical space2.34e-1195
immaterial anatomical entity2.99e-11117
organ3.98e-11503
oral opening7.24e-1122
epithelial fold1.03e-1047
nephron tubule epithelium1.55e-1010
organism subdivision4.19e-10264
thoracic cavity element8.00e-1034
thoracic cavity8.00e-1034
thoracic segment organ2.28e-0935
embryo2.68e-09592
hindgut1.27e-0819
mucosa2.14e-0820
mouth2.60e-0829
stomodeum2.60e-0829
surface structure3.98e-0899
developing anatomical structure5.60e-08581
organ part5.94e-08218
multi-tissue structure6.77e-08342
multi-cellular organism9.46e-08656
nephron epithelium9.57e-0815
renal tubule9.57e-0815
nephron tubule9.57e-0815
nephron9.57e-0815
uriniferous tubule9.57e-0815
nephrogenic mesenchyme9.57e-0815
subdivision of trunk1.29e-07112
respiratory primordium1.70e-0738
endoderm of foregut1.70e-0738
extraembryonic membrane2.27e-0714
membranous layer2.27e-0714
gut epithelium2.74e-0754
urothelium3.39e-075
tracheobronchial tree4.13e-0715
lower respiratory tract4.13e-0715
anatomical system4.17e-07624
excretory tube4.41e-0716
kidney epithelium4.41e-0716
gland4.78e-0759
anatomical group4.91e-07625
segment of respiratory tract5.05e-0747
organ system subdivision6.47e-07223
anterior region of body8.55e-0762
craniocervical region8.55e-0762
Disease
Ontology termp-valuen
squamous cell carcinoma1.25e-1314
carcinoma1.50e-12106


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.136928
MA0004.10.626788
MA0006.10.452993
MA0007.10.606704
MA0009.11.11255
MA0014.10.161847
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.10.470679
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.12.49194
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.288856
MA0056.10
MA0057.11.66737
MA0058.10.523638
MA0059.10.522232
MA0060.15.26847
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.692739
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.215829
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.10.522409
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.412364
MA0089.10
MA0090.10.556637
MA0091.11.52322
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.13.50906
MA0113.10.797251
MA0114.10.973423
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.11.23103
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.10.743749
MA0139.10.277033
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.442008
MA0146.10.143081
MA0147.10.386018
MA0148.11.57313
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.22.38271
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.20.320919
MA0047.20.767096
MA0112.20.425004
MA0065.20.146576
MA0150.12.32613
MA0151.10
MA0152.10.69926
MA0153.12.71958
MA0154.10.514087
MA0155.10.409315
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.11.00463
MA0160.10.669748
MA0161.10
MA0162.10.0592265
MA0163.10.0439995
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.21.66926
MA0079.21.53298
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CEBPB#105146.376918100659850.001113944176677320.00765591049407753
ELF1#199743.406478367046030.01235066105299550.0447381621016161
IRF1#365946.109731002851120.001315525264767990.00881057734558833
JUND#372745.595731153496820.001849593301755460.0109357832224886
MYC#460944.177825497287520.005691969036823440.0256865382291321
NFYA#4800414.74046455986444.14733626928016e-050.000752377371247786
NFYB#4801413.40783460282926.03169250119439e-050.00099156923206712
SP1#666744.558705102512720.00407573565781680.0194884056572992
TBP#690853.706770687096390.001428755106721120.0091933802347882



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.