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Coexpression cluster:C4628

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Full id: C4628_gastric_lung_medulla_astrocytoma_cerebellum_spinal_pineal



Phase1 CAGE Peaks

  Short description
Hg19::chr6:80247047..80247100,- p2@LCA5
Hg19::chr6:80247105..80247133,- p1@LCA5
Hg19::chr6:80247140..80247158,- p3@LCA5


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


No GOStat results

Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset


uberon_data


Uber Anatomy
Ontology termp-valuen
nervous system8.76e-3189
central nervous system4.47e-3081
adult organism8.99e-28114
neural tube3.59e-2656
neural rod3.59e-2656
future spinal cord3.59e-2656
neural keel3.59e-2656
ectoderm-derived structure1.08e-25171
ectoderm1.08e-25171
presumptive ectoderm1.08e-25171
brain8.80e-2568
future brain8.80e-2568
neurectoderm9.62e-2586
regional part of nervous system1.79e-2453
regional part of brain1.79e-2453
organ system subdivision2.66e-24223
neural plate5.46e-2482
presumptive neural plate5.46e-2482
anatomical cluster2.19e-23373
regional part of forebrain4.34e-2041
forebrain4.34e-2041
anterior neural tube4.34e-2041
future forebrain4.34e-2041
structure with developmental contribution from neural crest9.05e-20132
multi-tissue structure6.17e-18342
pre-chordal neural plate3.22e-1761
multi-cellular organism5.18e-17656
ecto-epithelium5.75e-17104
brain grey matter2.12e-1634
gray matter2.12e-1634
telencephalon3.09e-1634
regional part of telencephalon3.02e-1532
cerebral hemisphere3.66e-1532
anatomical conduit2.93e-13240
cerebral cortex3.45e-1225
pallium3.45e-1225
anatomical system4.81e-12624
regional part of cerebral cortex5.99e-1222
anatomical group6.20e-12625
embryo1.12e-11592
epithelium2.82e-11306
cell layer3.23e-11309
organ4.83e-11503
neocortex9.06e-1120
tube1.84e-10192
organ part2.82e-10218
developing anatomical structure6.70e-10581
embryonic structure8.44e-10564
germ layer1.37e-09560
germ layer / neural crest1.37e-09560
embryonic tissue1.37e-09560
presumptive structure1.37e-09560
germ layer / neural crest derived structure1.37e-09560
epiblast (generic)1.37e-09560
posterior neural tube2.79e-0715
chordal neural plate2.79e-0715


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.178364
MA0004.10.826076
MA0006.10.639288
MA0007.10.804807
MA0009.11.3275
MA0014.10.377374
MA0017.10.686276
MA0019.10.990656
MA0024.11.21731
MA0025.11.46617
MA0027.12.95767
MA0028.10.658629
MA0029.11.23771
MA0030.11.22561
MA0031.11.15713
MA0038.10.94098
MA0040.11.24388
MA0041.10.847069
MA0042.10.810843
MA0043.11.32783
MA0046.11.31611
MA0048.10.341392
MA0050.10.81185
MA0051.10.936307
MA0052.11.24796
MA0055.10.190716
MA0056.10
MA0057.10.886807
MA0058.10.716037
MA0059.10.714521
MA0060.18.03981
MA0061.10.456531
MA0063.10
MA0066.10.941452
MA0067.11.65513
MA0068.10.405474
MA0069.11.31207
MA0070.11.30033
MA0071.10.897953
MA0072.11.29561
MA0073.10.0185922
MA0074.10.935474
MA0076.10.734647
MA0077.11.28751
MA0078.11.04495
MA0081.10.714712
MA0083.11.33535
MA0084.11.84562
MA0087.11.29304
MA0088.10.257905
MA0089.10
MA0090.10.751469
MA0091.10.829044
MA0092.10.785956
MA0093.10.642957
MA0095.10
MA0098.10
MA0100.10.956299
MA0101.10.646932
MA0103.10.628063
MA0105.11.5295
MA0106.10.986396
MA0107.11.36919
MA0108.22.59836
MA0109.10
MA0111.11.80901
MA0113.11.00436
MA0114.11.35563
MA0115.11.57693
MA0116.10.560723
MA0117.11.36676
MA0119.10.695578
MA0122.11.39371
MA0124.11.53432
MA0125.11.44766
MA0130.10
MA0131.11.06461
MA0132.10
MA0133.10
MA0135.11.35921
MA0136.10.948776
MA0139.10.440097
MA0140.10.894983
MA0141.10.712476
MA0142.11.12317
MA0143.11.00455
MA0144.10.531867
MA0145.10.273764
MA0146.10.707589
MA0147.10.565108
MA0148.10.854239
MA0149.10.884158
MA0062.20.449458
MA0035.20.894194
MA0039.20.0526989
MA0138.21.04628
MA0002.21.20011
MA0137.20.666381
MA0104.20.491226
MA0047.20.973066
MA0112.20.264678
MA0065.21.39232
MA0150.10.744617
MA0151.10
MA0152.10.902317
MA0153.11.43021
MA0154.10.312019
MA0155.10.711948
MA0156.10.669101
MA0157.11.09377
MA0158.10
MA0159.10.565904
MA0160.10.871361
MA0161.10
MA0162.10.455568
MA0163.10.387745
MA0164.11.01792
MA0080.20.643061
MA0018.20.987913
MA0099.20.902716
MA0079.20.0373086
MA0102.21.88331
MA0258.10.519674
MA0259.10.575594
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CHD2#1106310.34402283411690.0009033701102746880.00662642723324752
EBF1#187938.9064668465690.00141523283560980.00918902717552082
ELF1#199734.258097958807540.01295179875054610.0464772165237865
FOS#235338.99795530889440.001372499272417130.00901638265894908
HMGN3#932438.178547723350590.001827766942164210.0109154935768921
IRF1#365937.63716375356390.002244692747297240.0128696456870321
IRF3#3661346.98195221148969.63568551583244e-060.000254126605956572
NFYA#4800318.42558069983050.0001598135507814160.0020020112066763
NFYB#4801316.75979325353650.0002123649923296180.00246627237116791
RFX5#5993312.04791082719510.0005717246050312580.0048675589814021
SETDB1#9869340.32002617801051.52461559299059e-050.000360003002297862
SIN3A#2594235.408884726815140.006318961977991520.0278188285638181
SP1#666735.69838137814090.005403962701712170.0247819645474715
SP2#6668326.15353049384465.58768218891694e-050.00094230896193815
SRF#6722313.79717826216780.0003806615025800190.00376333838204796
YY1#752834.911170749853860.008441455341808260.0331098942593275
ZBTB7A#5134137.35190930787590.002516255860282270.0140878763692516
ZEB1#6935211.25895467836260.01010222676646330.0378254924627204



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data


This analysis result is provided for C0 - C305 clusters.