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Coexpression cluster:C1646

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Full id: C1646_peripheral_occipital_caudate_parietal_putamen_duodenum_temporal



Phase1 CAGE Peaks

Hg19::chr11:83393280..83393295,-p15@DLG2
Hg19::chr11:83393303..83393342,-p8@DLG2
Hg19::chr11:83393429..83393454,-p12@DLG2
Hg19::chr2:133015374..133015390,-p3@ANKRD30BL
Hg19::chrX:91034366..91034380,+p1@PCDH11X


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0004385guanylate kinase activity0.018129910939371
GO:0019201nucleotide kinase activity0.0299614361024918
GO:0016776phosphotransferase activity, phosphate group as acceptor0.0299614361024918
GO:0044459plasma membrane part0.0299614361024918
GO:0019205nucleobase, nucleoside, nucleotide kinase activity0.0299614361024918
GO:0045211postsynaptic membrane0.0378242913176896
GO:0044456synapse part0.0378242913176896
GO:0007156homophilic cell adhesion0.0392454202050833
GO:0005886plasma membrane0.0392454202050833



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br><br>uberon_data<br><br>


Uber Anatomy
Ontology termp-valuen
neural tube2.64e-8456
neural rod2.64e-8456
future spinal cord2.64e-8456
neural keel2.64e-8456
regional part of nervous system3.60e-7953
regional part of brain3.60e-7953
central nervous system2.26e-7481
neurectoderm6.53e-7286
regional part of forebrain1.03e-7141
forebrain1.03e-7141
anterior neural tube1.03e-7141
future forebrain1.03e-7141
nervous system5.65e-6889
neural plate1.13e-6482
presumptive neural plate1.13e-6482
brain2.05e-6368
future brain2.05e-6368
brain grey matter3.89e-5934
gray matter3.89e-5934
telencephalon6.57e-5934
adult organism4.23e-58114
cerebral hemisphere6.87e-5632
regional part of telencephalon2.03e-5532
pre-chordal neural plate3.08e-5461
ecto-epithelium1.93e-51104
ectoderm-derived structure4.09e-44171
ectoderm4.09e-44171
presumptive ectoderm4.09e-44171
cerebral cortex6.64e-4225
pallium6.64e-4225
structure with developmental contribution from neural crest1.12e-41132
regional part of cerebral cortex3.49e-4122
neocortex3.34e-3720
organ system subdivision8.57e-28223
tube1.80e-19192
basal ganglion6.78e-199
nuclear complex of neuraxis6.78e-199
aggregate regional part of brain6.78e-199
collection of basal ganglia6.78e-199
cerebral subcortex6.78e-199
neural nucleus2.06e-189
nucleus of brain2.06e-189
anatomical cluster8.76e-17373
anatomical conduit2.30e-15240
telencephalic nucleus7.52e-157
posterior neural tube3.21e-1415
chordal neural plate3.21e-1415
diencephalon8.15e-147
future diencephalon8.15e-147
epithelium1.60e-13306
cell layer3.19e-13309
gyrus8.65e-136
brainstem3.93e-126
organ part6.88e-12218
limbic system1.03e-115
multi-tissue structure2.50e-11342
temporal lobe4.32e-116
parietal lobe4.58e-115
occipital lobe8.30e-115
corpus striatum6.08e-104
striatum6.08e-104
ventral part of telencephalon6.08e-104
future corpus striatum6.08e-104
segmental subdivision of hindbrain6.57e-1012
hindbrain6.57e-1012
presumptive hindbrain6.57e-1012
embryo4.69e-09592
segmental subdivision of nervous system5.05e-0913
embryonic structure5.63e-09564
germ layer1.21e-08560
germ layer / neural crest1.21e-08560
embryonic tissue1.21e-08560
presumptive structure1.21e-08560
germ layer / neural crest derived structure1.21e-08560
epiblast (generic)1.21e-08560
developing anatomical structure1.54e-08581
gland of diencephalon1.69e-084
neuroendocrine gland1.69e-084
regional part of diencephalon2.41e-084
caudate-putamen6.96e-083
dorsal striatum6.96e-083
frontal cortex2.31e-073
pons6.89e-073
medulla oblongata6.89e-073
myelencephalon6.89e-073
future myelencephalon6.89e-073


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.0497246
MA0004.10.626788
MA0006.11.14863
MA0007.10.606704
MA0009.11.11255
MA0014.10.161847
MA0017.10.496101
MA0019.10.784036
MA0024.11.00439
MA0025.11.24931
MA0027.12.73598
MA0028.11.18667
MA0029.11.02437
MA0030.11.01252
MA0031.10.945567
MA0038.10.736268
MA0040.11.03042
MA0041.10.64667
MA0042.10.612397
MA0043.11.11288
MA0046.11.10134
MA0048.10.195817
MA0050.10.613347
MA0051.10.731787
MA0052.11.03442
MA0055.10.288856
MA0056.10
MA0057.11.05691
MA0058.10.523638
MA0059.10.522232
MA0060.10.860776
MA0061.10.291022
MA0063.10
MA0066.10.736721
MA0067.11.43651
MA0068.10.247962
MA0069.11.09737
MA0070.11.08584
MA0071.10.695094
MA0072.11.0812
MA0073.10.0140295
MA0074.10.730989
MA0076.10.540943
MA0077.11.07324
MA0078.10.836493
MA0081.11.2972
MA0083.11.12028
MA0084.11.62584
MA0087.11.07867
MA0088.10.818263
MA0089.10
MA0090.10.556637
MA0091.10.629594
MA0092.10.588959
MA0093.10.456342
MA0095.10
MA0098.10
MA0100.10.750974
MA0101.10.459973
MA0103.10.442769
MA0105.10.175503
MA0106.10.779931
MA0107.10.378225
MA0108.20.94238
MA0109.10
MA0111.10.5713
MA0113.10.797251
MA0114.10.372523
MA0115.11.35895
MA0116.10.382106
MA0117.11.1512
MA0119.10.504689
MA0122.11.17777
MA0124.11.31673
MA0125.12.75442
MA0130.10
MA0131.10.855546
MA0132.10
MA0133.10
MA0135.11.14377
MA0136.11.76068
MA0139.10.759606
MA0140.10.692258
MA0141.10.520334
MA0142.10.912455
MA0143.10.797437
MA0144.10.356507
MA0145.10.442008
MA0146.10.0359558
MA0147.11.00307
MA0148.10.653474
MA0149.10.681935
MA0062.20.284987
MA0035.20.691506
MA0039.20.15493
MA0138.20.837782
MA0002.20.30855
MA0137.20.47779
MA0104.21.54865
MA0047.20.767096
MA0112.20.136971
MA0065.20.449243
MA0150.11.35623
MA0151.10
MA0152.10.69926
MA0153.11.21379
MA0154.10.172764
MA0155.10.409315
MA0156.10.480289
MA0157.10.883854
MA0158.10
MA0159.10.386729
MA0160.10.669748
MA0161.10
MA0162.10.21472
MA0163.11.99104
MA0164.10.810347
MA0080.20.456437
MA0018.20.781393
MA0099.20.699641
MA0079.20.230892
MA0102.21.66336
MA0258.10.345771
MA0259.10.395396
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.