Personal tools

Coexpression cluster:C696

From FANTOM5_SSTAR

Revision as of 19:22, 22 January 2013 by Autoedit (talk | contribs)
Jump to: navigation, search


Full id: C696_medial_occipital_temporal_amygdala_parietal_duodenum_cerebellum



Phase1 CAGE Peaks

Hg19::chr12:57980107..57980120,+p6@KIF5A
Hg19::chr14:24038741..24038779,-p@chr14:24038741..24038779
-
Hg19::chr14:60063171..60063197,-p@chr14:60063171..60063197
-
Hg19::chr14:60063407..60063420,-p@chr14:60063407..60063420
-
Hg19::chr19:42471468..42471486,-p@chr19:42471468..42471486
-
Hg19::chr1:183387432..183387443,-p9@NMNAT2
Hg19::chr1:6219506..6219520,-p@chr1:6219506..6219520
-
Hg19::chr2:149818477..149818509,+p4@KIF5C
Hg19::chr2:149880852..149880863,+p@chr2:149880852..149880863
+
Hg19::chr2:241679747..241679778,-p@chr2:241679747..241679778
-
Hg19::chr2:241727586..241727616,-p2@KIF1A
Hg19::chrX:102318624..102318646,-p2@BEX1


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0003777microtubule motor activity4.31307061549663e-05
GO:0007018microtubule-based movement4.31307061549663e-05
GO:0005875microtubule associated complex4.31307061549663e-05
GO:0030705cytoskeleton-dependent intracellular transport4.31307061549663e-05
GO:0005871kinesin complex0.000101134960161195
GO:0005874microtubule0.000101134960161195
GO:0007017microtubule-based process0.000102363837873752
GO:0015630microtubule cytoskeleton0.000393922153268168
GO:0007010cytoskeleton organization and biogenesis0.000813017179920108
GO:0046907intracellular transport0.00157929267129455
GO:0044430cytoskeletal part0.00157929267129455
GO:0051649establishment of cellular localization0.00244448456790267
GO:0051641cellular localization0.00244448456790267
GO:0035253ciliary rootlet0.00270779369921599
GO:0000309nicotinamide-nucleotide adenylyltransferase activity0.00270779369921599
GO:0005856cytoskeleton0.00390852402056889
GO:0008089anterograde axon cargo transport0.00398158069513317
GO:0006996organelle organization and biogenesis0.00431841749717366
GO:0044441cilium part0.00498686646998808
GO:0008088axon cargo transport0.00541399340658784
GO:0009435NAD biosynthetic process0.00966386179691905
GO:0019674NAD metabolic process0.00983898908286267
GO:0019363pyridine nucleotide biosynthetic process0.0135230356149226
GO:0006769nicotinamide metabolic process0.0157157848394654
GO:0005524ATP binding0.0157157848394654
GO:0032559adenyl ribonucleotide binding0.0157157848394654
GO:0042364water-soluble vitamin biosynthetic process0.0157157848394654
GO:0043234protein complex0.0157157848394654
GO:0043232intracellular non-membrane-bound organelle0.0157157848394654
GO:0043228non-membrane-bound organelle0.0157157848394654
GO:0019362pyridine nucleotide metabolic process0.0157157848394654
GO:0009110vitamin biosynthetic process0.0157157848394654
GO:0030554adenyl nucleotide binding0.0157157848394654
GO:0005929cilium0.016289917483026
GO:0044463cell projection part0.0181338635138292
GO:0006733oxidoreduction coenzyme metabolic process0.0187521610759297
GO:0016043cellular component organization and biogenesis0.019199745731352
GO:0044424intracellular part0.0195380484406782
GO:0006767water-soluble vitamin metabolic process0.0210586210832302
GO:0032553ribonucleotide binding0.0210586210832302
GO:0032555purine ribonucleotide binding0.0210586210832302
GO:0017076purine nucleotide binding0.0228038418528482
GO:0043005neuron projection0.025386786923073
GO:0032991macromolecular complex0.0257483418226147
GO:0006766vitamin metabolic process0.0257483418226147
GO:0006810transport0.0278101633781098
GO:0044446intracellular organelle part0.0279625372272735
GO:0044422organelle part0.0279625372272735
GO:0051234establishment of localization0.0279625372272735
GO:0000166nucleotide binding0.0293260869871864
GO:0005622intracellular0.0293260869871864
GO:0051179localization0.0329773797637642
GO:0009108coenzyme biosynthetic process0.0492532669303054



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
neuron2.02e-146
neuroblast2.02e-146
electrically signaling cell2.02e-146
neuronal stem cell3.11e-148
embryonic stem cell3.36e-115
Uber Anatomy
Ontology termp-valuen
central nervous system3.82e-9881
nervous system1.04e-9689
neural tube1.21e-9656
neural rod1.21e-9656
future spinal cord1.21e-9656
neural keel1.21e-9656
regional part of nervous system8.68e-9053
regional part of brain8.68e-9053
brain6.51e-7768
future brain6.51e-7768
regional part of forebrain3.01e-7441
forebrain3.01e-7441
anterior neural tube3.01e-7441
future forebrain3.01e-7441
brain grey matter3.81e-6734
gray matter3.81e-6734
telencephalon9.24e-6734
neural plate9.16e-6582
presumptive neural plate9.16e-6582
cerebral hemisphere1.44e-6232
regional part of telencephalon1.86e-6232
neurectoderm3.72e-6186
regional part of cerebral cortex2.03e-5322
ecto-epithelium7.34e-53104
pre-chordal neural plate1.89e-4961
ectoderm-derived structure7.91e-49171
ectoderm7.91e-49171
presumptive ectoderm7.91e-49171
neocortex1.81e-4820
cerebral cortex1.80e-4625
pallium1.80e-4625
adult organism4.57e-43114
structure with developmental contribution from neural crest3.55e-37132
organ system subdivision2.60e-35223
posterior neural tube2.56e-2215
chordal neural plate2.56e-2215
basal ganglion2.69e-229
nuclear complex of neuraxis2.69e-229
aggregate regional part of brain2.69e-229
collection of basal ganglia2.69e-229
cerebral subcortex2.69e-229
neural nucleus7.04e-229
nucleus of brain7.04e-229
tube2.43e-21192
telencephalic nucleus2.41e-177
gyrus2.55e-166
segmental subdivision of hindbrain3.52e-1612
hindbrain3.52e-1612
presumptive hindbrain3.52e-1612
anatomical cluster1.51e-15373
segmental subdivision of nervous system8.64e-1513
brainstem9.40e-156
anatomical conduit1.66e-14240
occipital lobe2.65e-145
temporal lobe3.61e-146
parietal lobe7.28e-145
limbic system1.11e-135
corpus striatum4.47e-114
striatum4.47e-114
ventral part of telencephalon4.47e-114
future corpus striatum4.47e-114
organ part5.48e-11218
epithelium1.34e-10306
cell layer2.26e-10309
regional part of metencephalon2.56e-109
metencephalon2.56e-109
future metencephalon2.56e-109
diencephalon3.87e-097
future diencephalon3.87e-097
frontal cortex4.45e-093
caudate-putamen6.63e-093
dorsal striatum6.63e-093
embryo7.59e-09592
pons2.08e-083
spinal cord4.11e-083
dorsal region element4.11e-083
dorsum4.11e-083
medulla oblongata5.01e-083
myelencephalon5.01e-083
future myelencephalon5.01e-083
germ layer5.45e-07560
germ layer / neural crest5.45e-07560
embryonic tissue5.45e-07560
presumptive structure5.45e-07560
germ layer / neural crest derived structure5.45e-07560
epiblast (generic)5.45e-07560
embryonic structure7.95e-07564
middle temporal gyrus8.30e-072
middle frontal gyrus9.52e-072


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.050563
MA0004.10.32225
MA0006.10.188769
MA0007.10.825205
MA0009.10.756202
MA0014.10.169227
MA0017.10.627635
MA0019.10.45566
MA0024.10.654931
MA0025.12.05423
MA0027.12.35633
MA0028.10.201461
MA0029.10.673506
MA0030.10.662482
MA0031.10.600685
MA0038.10.414169
MA0040.10.67914
MA0041.10.338572
MA0042.10.835565
MA0043.10.756508
MA0046.10.745626
MA0048.10.155795
MA0050.10.311321
MA0051.10.410316
MA0052.10.682867
MA0055.10.0371476
MA0056.10
MA0057.10.965996
MA0058.10.240796
MA0059.10.673606
MA0060.10.103131
MA0061.10.28989
MA0063.10
MA0066.10.414559
MA0067.11.06751
MA0068.10.0633085
MA0069.10.741884
MA0070.10.731026
MA0071.10.379038
MA0072.10.726666
MA0073.10.405793
MA0074.10.40963
MA0076.10.254045
MA0077.10.719193
MA0078.10.502027
MA0081.10.239862
MA0083.10.763502
MA0084.11.25286
MA0087.10.724294
MA0088.10.397386
MA0089.10
MA0090.11.35035
MA0091.13.27266
MA0092.10.793019
MA0093.10.191154
MA0095.10
MA0098.10
MA0100.10.426863
MA0101.10.19375
MA0103.10.535462
MA0105.10.307721
MA0106.10.452066
MA0107.10.137948
MA0108.20.597764
MA0109.10
MA0111.10.761158
MA0113.10.467266
MA0114.10.418165
MA0115.10.992167
MA0116.11.99055
MA0117.10.792789
MA0119.10.64269
MA0122.10.818044
MA0124.10.951337
MA0125.10.868909
MA0130.10
MA0131.10.519055
MA0132.10
MA0133.10
MA0135.10.785738
MA0136.11.07857
MA0139.10.567946
MA0140.10.376643
MA0141.10.238287
MA0142.10.570448
MA0143.11.17969
MA0144.10.39221
MA0145.10.232227
MA0146.10.139505
MA0147.10.143012
MA0148.10.344198
MA0149.10.367947
MA0062.20.0823902
MA0035.20.376007
MA0039.20.19592
MA0138.20.503176
MA0002.20.316618
MA0137.20.20663
MA0104.20.102626
MA0047.20.440861
MA0112.20.416057
MA0065.20.452385
MA0150.10.261236
MA0151.10
MA0152.10.995496
MA0153.10.852412
MA0154.10.875403
MA0155.10.202876
MA0156.10.600064
MA0157.10.544523
MA0158.10
MA0159.11.39808
MA0160.10.357736
MA0161.10
MA0162.10.00310762
MA0163.10.688273
MA0164.10.478818
MA0080.20.558855
MA0018.20.453345
MA0099.20.382887
MA0079.20.496387
MA0102.21.28978
MA0258.10.375
MA0259.10.149181
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


No analysis results for this cluster

Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.