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Coexpression cluster:C795

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Full id: C795_occipital_postcentral_Whole_temporal_paracentral_insula_parietal



Phase1 CAGE Peaks

Hg19::chr11:124609823..124609869,+p1@NRGN
Hg19::chr11:124615457..124615462,+p@chr11:124615457..124615462
+
Hg19::chr11:124615557..124615575,+p@chr11:124615557..124615575
+
Hg19::chr11:124616356..124616367,-p6@ENST00000531241
Hg19::chr11:124616378..124616428,-p2@ENST00000531241
Hg19::chr11:124616466..124616477,-p8@ENST00000531241
Hg19::chr11:124616487..124616565,-p1@ENST00000531241
Hg19::chr11:124616678..124616697,-p10@ENST00000531241
Hg19::chr11:124616843..124616873,-p@chr11:124616843..124616873
-
Hg19::chr16:2564254..2564305,+p@chr16:2564254..2564305
+


Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression cluster<b>Summary:</b> Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br>data


GO IDGO nameFDR corrected p-value
GO:0005516calmodulin binding0.0415047686329919



Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>


Cell Type
Ontology termp-valuen
CD14-positive, CD16-negative classical monocyte1.75e-1942
myeloid cell2.28e-19112
common myeloid progenitor2.28e-19112
myeloid leukocyte6.97e-1876
classical monocyte1.64e-1745
macrophage dendritic cell progenitor1.98e-1665
monopoietic cell3.25e-1663
monocyte3.25e-1663
monoblast3.25e-1663
promonocyte3.25e-1663
myeloid lineage restricted progenitor cell1.97e-1570
granulocyte monocyte progenitor cell2.85e-1571
hematopoietic stem cell1.86e-08172
angioblastic mesenchymal cell1.86e-08172
hematopoietic cell2.30e-08182
endothelial cell8.80e-0835
hematopoietic oligopotent progenitor cell9.40e-08165
hematopoietic multipotent progenitor cell9.40e-08165
endothelial cell of vascular tree1.65e-0724
blood vessel endothelial cell2.07e-0718
embryonic blood vessel endothelial progenitor cell2.07e-0718
Uber Anatomy
Ontology termp-valuen
lateral plate mesoderm2.60e-19216
hemolymphoid system3.38e-18112
hematopoietic system2.30e-17102
blood island2.30e-17102
telencephalon4.71e-1734
regional part of forebrain9.48e-1741
forebrain9.48e-1741
future forebrain9.48e-1741
neural tube1.10e-1657
neural rod1.10e-1657
future spinal cord1.10e-1657
neural keel1.10e-1657
gray matter1.33e-1634
brain grey matter1.33e-1634
cerebral hemisphere1.77e-1632
anterior neural tube1.78e-1642
regional part of telencephalon2.15e-1633
adult organism2.32e-15115
tube3.64e-15194
central nervous system1.35e-1482
neurectoderm2.91e-1490
regional part of brain4.75e-1459
neural plate1.47e-1386
presumptive neural plate1.47e-1386
brain1.63e-1369
future brain1.63e-1369
bone marrow1.95e-1380
regional part of cerebral cortex3.27e-1322
bone element3.77e-1386
cardiovascular system7.12e-13110
circulatory system8.75e-13113
pre-chordal neural plate2.72e-1261
cerebral cortex2.75e-1225
pallium2.75e-1225
regional part of nervous system4.20e-1294
nervous system4.20e-1294
neocortex4.56e-1220
anatomical conduit2.21e-10241
skeletal element2.51e-10101
skeletal system2.51e-10101
embryonic structure2.99e-10605
developing anatomical structure2.99e-10605
germ layer3.29e-10604
embryonic tissue3.29e-10604
presumptive structure3.29e-10604
epiblast (generic)3.29e-10604
embryo1.32e-09612
anatomical system1.38e-09625
vessel1.92e-0969
anatomical group1.94e-09626
tissue5.74e-09787
immune system6.12e-09115
vasculature6.48e-0979
vascular system6.48e-0979
blood vessel1.03e-0860
epithelial tube open at both ends1.03e-0860
blood vasculature1.03e-0860
vascular cord1.03e-0860
anatomical cluster1.06e-08286
musculoskeletal system1.30e-08167
blood4.04e-0815
haemolymphatic fluid4.04e-0815
organism substance4.04e-0815
cell layer1.70e-07312
endothelium2.07e-0718
blood vessel endothelium2.07e-0718
cardiovascular system endothelium2.07e-0718
epithelium3.44e-07309
multi-cellular organism5.00e-07659


Overrepresented TFBS (DNA) motifs on this co-expression cluster<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)

{{{tfbs_overrepresentation_jaspar}}}



ENCODE TF ChIP-seq peak enrichment analysis<b>Summary:</b> For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained. <br><b>Analyst:</b> Erik Arner<br><br>link to source dataset<br><br>data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#1488850.17360027146251.81009809364417e-132.75575560936011e-11
CTCF#1066463.216153823845020.004429095326154860.0209696852426804
EGR1#195873.49172536636710.0008771692339228240.00654221792627764
ELF1#199772.980668571165280.002378202870469130.0134723980033047
JUND#372764.196798365122620.001065203456546050.00752392694428604
RAD21#588555.177516947728160.001393960115380.00907177221399378
SMC3#912669.02695970695971.43128844366218e-050.00034229982543539
SP1#666763.419028826884540.003207339839120720.0168217428543127
YY1#752862.946702449912310.006987247873951880.029538197964285
ZNF143#770256.750438276113950.0004088269908565020.00389788954702047



Relative expression of the co-expression cluster<b>Summary:</b>Co-expression clusters are compared against FANTOM5 samples to obtain relative expression. <br><b>Analyst:</b>NA<br><br>link to data source<br> data


This analysis result is provided for C0 - C305 clusters.