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Coexpression cluster:C214

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Full id: C214_Neurons_Neural_duodenum_temporal_occipital_parietal_brain



Phase1 CAGE Peaks

  Short description
Hg19::chr10:112836138..112836159,+ p@chr10:112836138..112836159
+
Hg19::chr11:57335750..57335798,- p2@UBE2L6
Hg19::chr12:111471526..111471541,+ p1@CUX2
Hg19::chr12:124265636..124265639,+ p3@DNAH10
Hg19::chr13:112721131..112721138,+ p@chr13:112721131..112721138
+
Hg19::chr14:23956535..23956550,- p@chr14:23956535..23956550
-
Hg19::chr14:29235961..29236008,+ p1@FOXG1
Hg19::chr14:29236269..29236285,+ p3@FOXG1
Hg19::chr14:29236301..29236317,+ p5@FOXG1
Hg19::chr17:37764128..37764258,- p1@NEUROD2
Hg19::chr17:79008476..79008509,- p2@FLJ90757
Hg19::chr18:53069389..53069416,- p40@TCF4
Hg19::chr18:53069419..53069450,- p34@TCF4
Hg19::chr1:11539204..11539219,+ p1@PTCHD2
Hg19::chr1:151032922..151032951,+ p2@MLLT11
Hg19::chr1:151032957..151032968,+ p7@MLLT11
Hg19::chr20:656437..656451,- p4@SRXN1
Hg19::chr20:657349..657358,- p@chr20:657349..657358
-
Hg19::chr22:28197594..28197605,- p8@MN1
Hg19::chr22:42393540..42393558,+ p@chr22:42393540..42393558
+
Hg19::chr22:45404770..45404812,- p2@PHF21B
Hg19::chr22:45404819..45404830,- p5@PHF21B
Hg19::chr2:104496537..104496544,- p3@ENST00000455716
Hg19::chr2:104496562..104496570,- p2@ENST00000455716
Hg19::chr2:104496621..104496635,- p1@ENST00000455716
Hg19::chr2:105050903..105050923,+ p1@ENST00000447380
Hg19::chr2:105122941..105122944,+ p@chr2:105122941..105122944
+
Hg19::chr2:105470536..105470556,+ p4@POU3F3
Hg19::chr2:105470614..105470625,+ p7@POU3F3
Hg19::chr2:5835715..5835720,+ p@chr2:5835715..5835720
+
Hg19::chr2:5839854..5839869,+ p@chr2:5839854..5839869
+
Hg19::chr2:85413434..85413436,+ p1@TCF7L1-IT1
Hg19::chr3:115342138..115342157,+ p4@GAP43
Hg19::chr3:115342159..115342173,+ p5@GAP43
Hg19::chr3:36805787..36805798,- p@chr3:36805787..36805798
-
Hg19::chr3:77087811..77087819,+ p@chr3:77087811..77087819
+
Hg19::chr3:89156763..89156797,+ p1@EPHA3
Hg19::chr3:89156799..89156831,+ p3@EPHA3
Hg19::chr3:89156832..89156848,+ p2@EPHA3
Hg19::chr3:89156872..89156883,+ p4@EPHA3
Hg19::chr3:89156891..89156894,+ p5@EPHA3
Hg19::chr5:140613949..140613969,+ p3@PCDHB18
Hg19::chr5:146257992..146258003,- p18@PPP2R2B
Hg19::chr5:150284420..150284443,- p2@ZNF300
Hg19::chr5:58295564..58295588,- p59@PDE4D
Hg19::chr5:71479302..71479315,+ p@chr5:71479302..71479315
+
Hg19::chr5:87967371..87967404,- p@chr5:87967371..87967404
-
Hg19::chr6:13925142..13925163,+ p3@RNF182
Hg19::chr6:13925170..13925234,+ p1@RNF182
Hg19::chr6:155334892..155334903,+ p18@TIAM2
Hg19::chr6:21594206..21594221,+ p15@SOX4
Hg19::chr6:21594252..21594285,+ p11@SOX4
Hg19::chr6:88876117..88876157,+ p@chr6:88876117..88876157
+
Hg19::chr6:88877062..88877073,- p3@BC037581
Hg19::chr7:133261209..133261224,+ p7@EXOC4
Hg19::chr7:133261274..133261284,+ p10@EXOC4
Hg19::chr7:24323800..24323815,+ p1@NPY
Hg19::chr7:24324837..24324863,+ p2@NPY
Hg19::chr7:31380440..31380451,- p4@NEUROD6
Hg19::chr7:80548757..80548764,- p14@SEMA3C
Hg19::chr7:80632805..80632821,- p@chr7:80632805..80632821
-
Hg19::chr8:134114832..134114863,- p9@SLA
Hg19::chr8:134114866..134114880,- p11@SLA
Hg19::chr8:134114887..134114896,- p15@SLA
Hg19::chr8:134115035..134115072,- p12@SLA
Hg19::chr8:134115118..134115121,- p13@SLA
Hg19::chr9:14308004..14308041,- p14@NFIB
Hg19::chr9:34990264..34990312,+ p3@DNAJB5
Hg19::chr9:38424443..38424458,- p1@IGFBPL1


Enriched pathways on this co-expression clusterSummary:
Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.
Analyst: Emmanuel Dimont

link to source dataset
data


No results for this coexpression

Enriched Gene Ontology terms on this co-expression clusterSummary: Results for GOStat analysis on co-expressed clusters. Each cluster with promoters mapping to at least two different genes was analysed with GOStat (PMID: 14962934) with default parameter.
Analyst: Erik Arner

link to source dataset
data


GO IDGO nameFDR corrected p-value
GO:0050789regulation of biological process0.0220708125053184
GO:0065007biological regulation0.0497479221438013



Enriched sample ontology terms on this co-expression clusterSummary:To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. Analyst: Hideya Kawaji

links to source dataset

cell_data
uberon_data


Cell Type
Ontology termp-valuen
neuronal stem cell1.04e-128
neural cell2.51e-1225
astrocyte of the cerebral cortex1.15e-113
oligodendrocyte2.19e-087
macroglial cell2.19e-087
astrocyte2.19e-087
oligodendrocyte precursor cell2.19e-087
Uber Anatomy
Ontology termp-valuen
regional part of nervous system1.33e-8053
regional part of brain1.33e-8053
central nervous system3.02e-7881
neural tube6.76e-7656
neural rod6.76e-7656
future spinal cord6.76e-7656
neural keel6.76e-7656
nervous system1.29e-6989
brain6.35e-6868
future brain6.35e-6868
telencephalon6.51e-6734
brain grey matter1.04e-6634
gray matter1.04e-6634
cerebral hemisphere6.01e-6632
regional part of forebrain1.49e-6341
forebrain1.49e-6341
anterior neural tube1.49e-6341
future forebrain1.49e-6341
regional part of telencephalon1.40e-6032
neurectoderm1.72e-5586
neural plate2.29e-5582
presumptive neural plate2.29e-5582
cerebral cortex6.12e-5425
pallium6.12e-5425
pre-chordal neural plate5.75e-4761
ecto-epithelium1.86e-44104
regional part of cerebral cortex2.33e-4422
neocortex3.55e-4320
ectoderm-derived structure1.76e-39171
ectoderm1.76e-39171
presumptive ectoderm1.76e-39171
structure with developmental contribution from neural crest3.68e-33132
adult organism2.84e-25114
organ system subdivision3.98e-25223
segmental subdivision of hindbrain2.00e-1712
hindbrain2.00e-1712
presumptive hindbrain2.00e-1712
tube2.88e-16192
segmental subdivision of nervous system5.48e-1613
gyrus2.79e-156
brainstem2.00e-146
neural nucleus3.53e-149
nucleus of brain3.53e-149
posterior neural tube1.09e-1315
chordal neural plate1.09e-1315
temporal lobe1.11e-136
regional part of metencephalon1.45e-139
metencephalon1.45e-139
future metencephalon1.45e-139
anatomical cluster1.85e-13373
occipital lobe1.02e-125
parietal lobe1.19e-125
organ part2.59e-12218
anatomical conduit2.38e-11240
pons3.19e-113
basal ganglion2.21e-109
nuclear complex of neuraxis2.21e-109
aggregate regional part of brain2.21e-109
collection of basal ganglia2.21e-109
cerebral subcortex2.21e-109
epithelium3.20e-09306
corpus striatum3.31e-094
striatum3.31e-094
ventral part of telencephalon3.31e-094
future corpus striatum3.31e-094
cell layer4.77e-09309
telencephalic nucleus8.79e-097
multi-tissue structure1.16e-08342
middle temporal gyrus2.17e-082
locus ceruleus5.63e-082
brainstem nucleus5.63e-082
hindbrain nucleus5.63e-082
limbic system1.11e-075
embryo2.08e-07592


Overrepresented TFBS (DNA) motifs on this co-expression clusterSummary:The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. Analyst: Michiel de Hoon

link to source data
Novel motifs
data

Jaspar motifs
data


Novel motifs



JASPAR motifs

Motifs-log10(p-value)
MA0003.10.42818
MA0004.10.292819
MA0006.10.405663
MA0007.10.044566
MA0009.10.174008
MA0014.11.57816
MA0017.10.0463903
MA0019.11.86615
MA0024.10.117627
MA0025.10.259105
MA0027.11.6012
MA0028.10.0862706
MA0029.10.127243
MA0030.11.26033
MA0031.10.633907
MA0038.12.09132
MA0040.10.407817
MA0041.10.328436
MA0042.10.26828
MA0043.10.174193
MA0046.10.167685
MA0048.10.193663
MA0050.10.131075
MA0051.10.501875
MA0052.10.412906
MA0055.10.779028
MA0056.10
MA0057.14.765
MA0058.10.141239
MA0059.10.261771
MA0060.11.98193
MA0061.11.10844
MA0063.10
MA0066.10.819409
MA0067.10.395513
MA0068.10.917665
MA0069.10.165471
MA0070.10.933424
MA0071.10.221073
MA0072.10.474249
MA0073.14.49448
MA0074.10.268282
MA0076.10.0040355
MA0077.10.152309
MA0078.10.0524643
MA0081.10.139784
MA0083.10.178428
MA0084.10.550575
MA0087.10.470858
MA0088.10.406748
MA0089.10
MA0090.10.0276887
MA0091.10.14696
MA0092.10.405655
MA0093.10.264179
MA0095.10
MA0098.10
MA0100.10.545306
MA0101.10.427346
MA0103.10.0636
MA0105.11.43213
MA0106.10.339698
MA0107.11.67332
MA0108.20.627577
MA0109.10
MA0111.10.364669
MA0113.10.366819
MA0114.10.112981
MA0115.10.336593
MA0116.10.0096387
MA0117.10.196603
MA0119.10.229097
MA0122.10.610429
MA0124.10.305891
MA0125.12.76875
MA0130.10
MA0131.10.212314
MA0132.10
MA0133.10
MA0135.13.16332
MA0136.10.0288258
MA0139.10.460563
MA0140.11.39065
MA0141.10.0185913
MA0142.11.98308
MA0143.11.45011
MA0144.10.0187744
MA0145.10.0173041
MA0146.10.01456
MA0147.10.132609
MA0148.12.0311
MA0149.10.396309
MA0062.20.0285313
MA0035.21.00608
MA0039.20.0217501
MA0138.20.195748
MA0002.20.146685
MA0137.20.485005
MA0104.20.0545669
MA0047.21.77543
MA0112.20.0409959
MA0065.20.815041
MA0150.10.0259029
MA0151.10
MA0152.10.22632
MA0153.10.235667
MA0154.10.117891
MA0155.10.614755
MA0156.10.0388696
MA0157.10.240059
MA0158.10
MA0159.10.000295811
MA0160.10.0736503
MA0161.10
MA0162.10.890371
MA0163.11.5425
MA0164.11.06483
MA0080.20.26439
MA0018.20.147652
MA0099.20.0205578
MA0079.26.55484
MA0102.20.582837
MA0258.10.0794531
MA0259.10.0776655
MA0442.10



ENCODE TF ChIP-seq peak enrichment analysisSummary: For each TF and each co-expression cluster, the number of promoters with ENCODE TF ChIP signal was compared with the rest of promoters from the robust set using Fisher's exact test. Clusters with significant ChIP enrichment (q <= 0.05) after Benjamini-Hochberg correction were retained.
Analyst: Erik Arner

link to source dataset

data


(#promoters = Number of promoters in this coexpression cluster that have ChIP signal of the TF)

TF#promotersEnrichmentp-valueq-value
CTBP2#148876.362594237323140.0001184378806711440.0016085219531097
NANOG#7992383.390698954320310.002432156040432350.0136985355501652
RAD21#5885203.001459100132275.22739825425055e-060.000160100951987001
TRIM28#1015592.424851092860330.01146805013066140.0419484340009858
ZNF263#10127222.621456753829491.35558385273272e-050.000328482185604531



Relative expression of the co-expression clusterSummary:Co-expression clusters are compared against FANTOM5 samples to obtain relative expression.
Analyst:NA

link to data source
data