MCL coexpression mm9:313
From FANTOM5_SSTAR
Phase1 CAGE Peaks
Enriched pathways on this co-expression cluster<b>Summary:</b><br>Canonical pathway gene sets were compiled from Reactome, Wikipathways and KEGG. For the major signaling pathways, the transcriptionally-regulated genes (downstream targets) were obtained from Netpath. Combined, the canonical pathways and downstream targets totaled 489 human gene sets. The corresponding M. musculus gene sets were inferred by homology using the HomoloGene database. Enrichment for each of the canonical 489 pathways and gene sets included in the co-expression cluster was assessed by the hypergeometric probability. The resulting P values were also then adjusted by the Benjamini-Hochberg method for multiple comparisons.<br><b>Analyst: </b>Emmanuel Dimont<br><br>link to source dataset<br>data
| GO ID | GO name | FDR corrected p-value |
|---|---|---|
| GO:0048790 | maintenance of presynaptic active zone structure | 0.00646469073576947 |
| GO:0031630 | regulation of synaptic vesicle fusion to presynaptic membrane | 0.00646469073576947 |
| GO:0051602 | response to electrical stimulus | 0.00646469073576947 |
| GO:0031629 | synaptic vesicle fusion to presynaptic membrane | 0.00646469073576947 |
| GO:0031338 | regulation of vesicle fusion | 0.00646469073576947 |
| GO:0050975 | sensory perception of touch | 0.00646469073576947 |
| GO:0006542 | glutamine biosynthetic process | 0.00861887926606475 |
| GO:0004356 | glutamate-ammonia ligase activity | 0.00861887926606475 |
| GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity | 0.00861887926606475 |
| GO:0016211 | ammonia ligase activity | 0.0105768461489581 |
| GO:0004965 | GABA-B receptor activity | 0.0105768461489581 |
| GO:0006906 | vesicle fusion | 0.0119318713726987 |
| GO:0016880 | acid-ammonia (or amide) ligase activity | 0.0119318713726987 |
| GO:0016188 | synaptic vesicle maturation | 0.0129251316475187 |
| GO:0003016 | respiratory system process | 0.0129251316475187 |
| GO:0048488 | synaptic vesicle endocytosis | 0.0193829176417405 |
| GO:0016079 | synaptic vesicle exocytosis | 0.0250775914657576 |
| GO:0016050 | vesicle organization and biogenesis | 0.0251874396635394 |
| GO:0007274 | neuromuscular synaptic transmission | 0.0251874396635394 |
| GO:0009084 | glutamine family amino acid biosynthetic process | 0.0251874396635394 |
| GO:0006541 | glutamine metabolic process | 0.0276739554004592 |
| GO:0017157 | regulation of exocytosis | 0.0316914421788287 |
| GO:0015020 | glucuronosyltransferase activity | 0.0319950096254669 |
| GO:0006944 | membrane fusion | 0.0354944803059186 |
| GO:0048489 | synaptic vesicle transport | 0.0356206229408446 |
| GO:0008067 | metabotropic glutamate, GABA-B-like receptor activity | 0.0387085213234202 |
| GO:0016917 | GABA receptor activity | 0.0401355710100174 |
| GO:0009064 | glutamine family amino acid metabolic process | 0.0413610703076045 |
| GO:0009791 | post-embryonic development | 0.0413610703076045 |
| GO:0005737 | cytoplasm | 0.0423500080886129 |
| GO:0008652 | amino acid biosynthetic process | 0.0436708464995313 |
Relative expression of the co-expression cluster over median <br>Analyst:
Enriched sample ontology terms on this co-expression cluster<b>Summary:</b>To summarize promoter activities (expression profile of a TSS region) across ~1000 samples, we performed enrichment analysis based on FANTOM5 Sample Ontology (FF ontology). The question here is “in which type of samples the promoter is more active”. To answer this question, we compared expressions (TPMs) in the samples associated with a sample ontology term and the rest of the samples by using the Mann-Whitney rank sum test. To summarize ontologies enriched in this co-expression cluster, we ran the same analysis on an averaged expression profile of all promoters that make up. <b>Analyst:</b> Hideya Kawaji <br><br>links to source dataset<br><br>cell_data<br>uberon_data<br><br>
| Ontology term | p-value | n |
|---|---|---|
| CNS neuron (sensu Vertebrata) | 1.11e-24 | 23 |
| neuroblast (sensu Vertebrata) | 1.11e-24 | 23 |
| neural cell | 2.41e-17 | 43 |
| ectodermal cell | 8.62e-17 | 44 |
| neurectodermal cell | 8.62e-17 | 44 |
| neuron | 1.92e-15 | 33 |
| neuronal stem cell | 1.92e-15 | 33 |
| neuroblast | 1.92e-15 | 33 |
| electrically signaling cell | 1.92e-15 | 33 |
| non-terminally differentiated cell | 2.28e-14 | 49 |
| electrically responsive cell | 3.30e-12 | 39 |
| electrically active cell | 3.30e-12 | 39 |
| embryonic cell | 4.37e-08 | 70 |
| neuron of the substantia nigra | 9.60e-07 | 3 |
TFBS overrepresentation<b>Summary:</b>The values shown are the p-values for overrepresentation of the motif in this coexpression cluster. So a small p-value means a strong overrepresentation. <b>Analyst:</b> Michiel de Hoon <br><br>link to source data <br> Novel motifs <br>data <br><br> Jaspar motifs <br>data
Novel motifs
JASPAR motifs
| Motifs | -log10(p-value) |
|---|---|
| MA0003.1 | 0.0475636 |
| MA0004.1 | 0.358028 |
| MA0006.1 | 0.0376667 |
| MA0007.1 | 0.336966 |
| MA0009.1 | 0.425374 |
| MA0014.1 | 0.000341065 |
| MA0017.1 | 0.398085 |
| MA0019.1 | 0.279241 |
| MA0024.1 | 0.388875 |
| MA0025.1 | 0.630472 |
| MA0027.1 | 2.00714 |
| MA0028.1 | 0.364782 |
| MA0029.1 | 2.59587 |
| MA0030.1 | 0.376415 |
| MA0031.1 | 0.347586 |
| MA0038.1 | 0.578883 |
| MA0040.1 | 0.435948 |
| MA0041.1 | 0.256066 |
| MA0042.1 | 0.514842 |
| MA0043.1 | 0.5085 |
| MA0046.1 | 0.45588 |
| MA0048.1 | 0.0168999 |
| MA0050.1 | 0.414313 |
| MA0051.1 | 0.593414 |
| MA0052.1 | 0.442788 |
| MA0055.1 | 0.0541681 |
| MA0056.1 | 0 |
| MA0057.1 | 0.108538 |
| MA0058.1 | 0.231244 |
| MA0059.1 | 0.246439 |
| MA0060.1 | 0.0168335 |
| MA0061.1 | 0.468254 |
| MA0063.1 | 0 |
| MA0066.1 | 1.06752 |
| MA0067.1 | 0.732677 |
| MA0068.1 | 0.796791 |
| MA0069.1 | 0.443076 |
| MA0070.1 | 0.434849 |
| MA0071.1 | 0.81947 |
| MA0072.1 | 0.427684 |
| MA0073.1 | 0.0117568 |
| MA0074.1 | 0.504232 |
| MA0076.1 | 0.438642 |
| MA0077.1 | 1.05438 |
| MA0078.1 | 0.228674 |
| MA0081.1 | 0.275922 |
| MA0083.1 | 0.507806 |
| MA0084.1 | 1.04444 |
| MA0087.1 | 0.470385 |
| MA0088.1 | 0.332218 |
| MA0089.1 | 0 |
| MA0090.1 | 0.64191 |
| MA0091.1 | 0.376809 |
| MA0092.1 | 0.310962 |
| MA0093.1 | 0.381754 |
| MA0095.1 | 0 |
| MA0098.1 | 0 |
| MA0100.1 | 0.161426 |
| MA0101.1 | 0.257705 |
| MA0103.1 | 0.188828 |
| MA0105.1 | 0.361908 |
| MA0106.1 | 0.66073 |
| MA0107.1 | 0.181933 |
| MA0108.2 | 0.296634 |
| MA0109.1 | 0 |
| MA0111.1 | 1.12049 |
| MA0113.1 | 0.214338 |
| MA0114.1 | 0.746323 |
| MA0115.1 | 0.51095 |
| MA0116.1 | 0.14839 |
| MA0117.1 | 0.48285 |
| MA0119.1 | 0.258451 |
| MA0122.1 | 0.500096 |
| MA0124.1 | 0.683426 |
| MA0125.1 | 0.615761 |
| MA0130.1 | 0 |
| MA0131.1 | 0.27582 |
| MA0132.1 | 0 |
| MA0133.1 | 0 |
| MA0135.1 | 3.37303 |
| MA0136.1 | 0.181597 |
| MA0139.1 | 0.302141 |
| MA0140.1 | 0.486044 |
| MA0141.1 | 1.223 |
| MA0142.1 | 0.336004 |
| MA0143.1 | 0.641011 |
| MA0144.1 | 0.249943 |
| MA0145.1 | 1.01256 |
| MA0146.1 | 0.0438234 |
| MA0147.1 | 0.11258 |
| MA0148.1 | 0.381264 |
| MA0149.1 | 0.0766295 |
| MA0062.2 | 0.597388 |
| MA0035.2 | 0.493344 |
| MA0039.2 | 0.00121157 |
| MA0138.2 | 0.743216 |
| MA0002.2 | 0.153717 |
| MA0137.2 | 0.457011 |
| MA0104.2 | 0.175212 |
| MA0047.2 | 0.199051 |
| MA0112.2 | 0.763683 |
| MA0065.2 | 1.01637 |
| MA0150.1 | 0.10301 |
| MA0151.1 | 0 |
| MA0152.1 | 0.577815 |
| MA0153.1 | 0.55531 |
| MA0154.1 | 1.11864 |
| MA0155.1 | 0.285814 |
| MA0156.1 | 0.436777 |
| MA0157.1 | 0.310784 |
| MA0158.1 | 0 |
| MA0159.1 | 0.29096 |
| MA0160.1 | 0.385618 |
| MA0161.1 | 0 |
| MA0162.1 | 0.0318231 |
| MA0163.1 | 0.342386 |
| MA0164.1 | 0.181834 |
| MA0080.2 | 0.0486268 |
| MA0018.2 | 0.188226 |
| MA0099.2 | 0.26517 |
| MA0079.2 | 6.5347e-05 |
| MA0102.2 | 1.09525 |
| MA0258.1 | 0.691186 |
| MA0259.1 | 0.252756 |
| MA0442.1 | 0 |
